Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.45 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | NGLY1 | Q96IV0 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631102 | 0.88 | AKR1C3 (0.47) | AKR1C3AKR1C2MAPTALDH1A1POLB | |
| SCHEMBL8635252 | 0.87 | AKR1C3 (0.50) | AKR1C3AKR1C2MAPTGFERALDH1A1 | |
| SCHEMBL8633408 | 0.87 | ALDH1A1 (0.39) | ALDH1A1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8635344 | 0.87 | KMT2A (0.36) | ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL8632908 | 0.86 | PTGS1 (0.43) | GAAMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8635848 | 0.85 | CYP11B2 (0.46) | MAPTALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL8634936 | 0.85 | AKR1C3 (0.48) | AKR1C3AKR1C2MAPTALDH1A1POLB | |
| SCHEMBL8637536 | 0.84 | AKR1C3 (0.51) | AKR1C3AKR1C2MAPTGFERGAA | |
| SCHEMBL8635140 | 0.84 | BCAT2 (0.42) | AKR1C3AKR1C2BCAT2MAPTALOX15 | |
| SCHEMBL8636232 | 0.84 | PTGS2 (0.40) | AKR1C3MAPTKDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1057999-C | 4-Aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 2000-11-01 | — | — | CN | disclosed |
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |
| CN-1138575-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 1996-12-25 | — | — | CN | disclosed |