Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8634968 | 0.84 | DRD4 (0.57) | KDM4EL3MBTL1CYP2D6ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8629946 | 0.83 | DRD4 (0.56) | KDM4EL3MBTL1CYP2D6ALDH1A1LMNA | |
| SCHEMBL8630535 | 0.82 | SIGMAR1 (0.53) | KDM4ECYP2D6ALDH1A1MAPTTSHR | |
| SCHEMBL8628212 | 0.82 | SMO (0.42) | KDM4EL3MBTL1ADRB1HSD17B10DRD4 | |
| SCHEMBL8628179 | 0.81 | KDM4E (0.50) | KDM4EALDH1A1LMNAHSD17B10DRD4 | |
| SCHEMBL8633168 | 0.80 | HTR3A (0.55) | L3MBTL1LRRK2ALDH1A1LMNAHSD17B10 | |
| SCHEMBL8627836 | 0.76 | DRD4 (0.45) | KDM4EL3MBTL1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL8630532 | 0.74 | DRD2 (0.46) | L3MBTL1ALDH1A1HSD17B10TRPV1DRD4 | |
| SCHEMBL8628029 | 0.74 | DRD2 (0.46) | L3MBTL1HSD17B10PPARGPPARADRD4 | |
| SCHEMBL8633681 | 0.73 | RECQL (0.50) | L3MBTL1HSD17B10DRD4GRM2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |