Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.36 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.36 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8638285 | 0.87 | PDE4B (0.41) | LMNAMAPT | |
| SCHEMBL8635192 | 0.87 | RXRA (0.35) | KCNJ6KCNJ5KCNJ3LMNASLC9A1 | |
| SCHEMBL8635012 | 0.87 | NSD2 (0.36) | POLBMAPTSLC9A1 | |
| SCHEMBL8635349 | 0.86 | ALDH1A1 (0.39) | ALDH1A1LMNAPOLBKDM4EMAPT | |
| SCHEMBL8635339 | 0.84 | MTNR1A (0.42) | ALDH1A1LMNA | |
| SCHEMBL7768676 | 0.84 | SLC9A1 (0.56) | SLC9A1 | |
| SCHEMBL8635870 | 0.83 | KCNJ6 (0.39) | KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL8635496 | 0.81 | ALDH1A1 (0.39) | ALDH1A1KCNJ6KCNJ5KCNJ3LMNA | |
| SCHEMBL8635629 | 0.81 | FLT1 (0.36) | ALDH1A1KCNJ6KCNJ5KCNJ3POLB | |
| SCHEMBL8634555 | 0.81 | MKNK1 (0.38) | LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1057999-C | 4-Aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 2000-11-01 | — | — | CN | disclosed |
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |
| CN-1138575-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 1996-12-25 | — | — | CN | disclosed |