Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | P4HB | P07237 | 3/20 | 0.37 |
| ▸ | PER2 | O15055 | 1/20 | 0.35 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.35 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633950 | 0.88 | SIRT2 (0.35) | NR1H3PDK1 | |
| SCHEMBL8633199 | 0.87 | PER2 (0.36) | KCNJ6KCNJ5KCNJ3P4HBPER2 | |
| SCHEMBL7764059 | 0.85 | SLC9A1 (0.53) | — | |
| SCHEMBL8638285 | 0.84 | PDE4B (0.41) | PDE4B | |
| SCHEMBL8635012 | 0.84 | NSD2 (0.36) | — | |
| SCHEMBL8634338 | 0.83 | ALDH1A1 (0.38) | KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL8635339 | 0.81 | MTNR1A (0.42) | — | |
| SCHEMBL8635768 | 0.80 | ALDH1A1 (0.37) | — | |
| SCHEMBL8635629 | 0.78 | FLT1 (0.36) | KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL8634555 | 0.78 | MKNK1 (0.38) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |