Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635629 | 0.89 | FLT1 (0.36) | RXRARXRBRXRGSLC9A1LTC4S | |
| SCHEMBL8635012 | 0.87 | NSD2 (0.36) | RXRARXRBRXRGSLC9A1L3MBTL1 | |
| SCHEMBL8634338 | 0.87 | ALDH1A1 (0.38) | SLC9A1GPBAR1LMNAKCNJ6KCNJ5 | |
| SCHEMBL8635732 | 0.87 | KCNJ6 (0.38) | GPBAR1LTC4SKCNJ6KCNJ3 | |
| SCHEMBL8634267 | 0.85 | KEAP1 (0.41) | RXRARXRBRXRGKMT2ALMNA | |
| SCHEMBL8636231 | 0.85 | MCL1 (0.33) | RXRARXRBKMT2AL3MBTL1LMNA | |
| SCHEMBL8635329 | 0.85 | SLC9A1 (0.35) | RXRARXRBRXRGSLC9A1L3MBTL1 | |
| SCHEMBL8633950 | 0.84 | SIRT2 (0.35) | RXRARXRBRXRGSLC9A1 | |
| SCHEMBL7764817 | 0.82 | SLC9A1 (0.60) | SLC9A1 | |
| SCHEMBL8635496 | 0.81 | ALDH1A1 (0.39) | SLC9A1KMT2AL3MBTL1LMNAKCNJ6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1057999-C | 4-Aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 2000-11-01 | — | — | CN | disclosed |
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |
| CN-1138575-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 1996-12-25 | — | — | CN | disclosed |