Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | PSMD10 | O75832 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8646966 | 0.87 | CA2 (0.46) | MTNR1AMTNR1BCA2PSMD10MAPT | |
| SCHEMBL8645804 | 0.84 | SMN1; SMN2 (0.44) | MTNR1ACA2PSMD10TP53CA12 | |
| SCHEMBL8788554 | 0.83 | PSMD10 (0.41) | MTNR1AMTNR1BCA2PSMD10 | |
| SCHEMBL4351623 | 0.78 | MPO (0.54) | — | |
| SCHEMBL8650318 | 0.78 | THRB (0.39) | MTNR1ACA2PSMD10MAPTCA12 | |
| SCHEMBL8649697 | 0.76 | SMN1; SMN2 (0.46) | MTNR1ACA2TP53CA12CA1 | |
| SCHEMBL9213281 | 0.76 | HTR2A (0.48) | — | |
| SCHEMBL16433177 | 0.75 | MPO (0.55) | — | |
| SCHEMBL4793354 | 0.74 | FKBP1A (0.52) | CA2PSMD10MAPTCA1 | |
| SCHEMBL8780822 | 0.72 | ALDH1A1 (0.44) | PSMD10CYP24A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763444-A | CENTRAL NERVOUS SYSTEM AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0761666-A2 | Antidepressant 1-arylalkyl-4-(alkoxypyridinyl)- or 4-(alkoxypyrimidinyl)piperazine derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-03-12 | — | — | EP | disclosed |