Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 7/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.53 |
| ▸ | RORA | P35398 | 2/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.53 |
| ▸ | RORB | Q92753 | 2/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.53 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.53 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6828511 | 0.82 | HCRTR2 (0.73) | RORCHCRTR2ESR1KDM1A | |
| SCHEMBL8656643 | 0.81 | KEAP1 (0.54) | RORCNR1I2RORANR1H2RORB | |
| SCHEMBL8656600 | 0.75 | HCRTR2 (0.52) | HCRTR2ESR1KMT2ANPSR1MAPT | |
| SCHEMBL156260 | 0.73 | KIF11 (0.59) | TSHR | |
| SCHEMBL28383987 | 0.72 | HCRTR2 (0.46) | RORCNR1I2RORANR1H2RORB | |
| SCHEMBL30326344 | 0.72 | HCRTR2 (0.46) | RORCNR1I2RORANR1H2RORB | |
| SCHEMBL3636387 | 0.71 | LMNA (0.63) | HCRTR2KMT2AKDM1AMAPT | |
| SCHEMBL21339855 | 0.70 | CYP19A1 (0.51) | RORCNR1I2RORANR1H2RORB | |
| SCHEMBL15853614 | 0.69 | HSD11B1 (0.76) | RORCNR1I2RORANR1H2RORB | |
| SCHEMBL14350007 | 0.68 | RORC (0.54) | RORCNR1I2RORANR1H2RORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780642-A | NON-STEROIDAL ANTIINFLAMMATORY AGENT WHICH BLOCKS RELEASE OF ARACHIDONIC ACID FROM PHOSPHOLIPIDS; SIDE EFFECT REDUCTION | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-07-14 | — | — | US | disclosed |