Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 known ✓ | P09917 | 2/20 | 0.53 |
| ▸ | NSD2 | O96028 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | ACR | P10323 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2673549 | 0.88 | MAPT (0.51) | NSD2MAPTSMN1; SMN2ALOX5ALDH1A1 | |
| SCHEMBL5075975 | 0.84 | HTT (0.47) | MAPTSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL130184 | 0.83 | PARP10 (0.57) | NSD2MAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL27992061 | 0.83 | NSD2 (0.57) | NSD2MAPTSMN1; SMN2ALOX5ALDH1A1 | |
| SCHEMBL2035745 | 0.82 | NSD2 (0.74) | NSD2MAPTSMN1; SMN2ALOX5ALDH1A1 | |
| SCHEMBL8669360 | 0.82 | NSD2 (0.56) | NSD2MAPTSMN1; SMN2ALOX5ALDH1A1 | |
| Sulfuric Acid SCHEMBL6246551 | 0.81 | MAPT (0.61) | NSD2MAPTSMN1; SMN2ALOX5ALDH1A1 | |
| SCHEMBL28181981 | 0.79 | LCK (0.62) | NSD2MAPTSMN1; SMN2ALOX5ALDH1A1 | |
| Sulfuric Acid SCHEMBL8528908 | 0.77 | PARP10 (0.61) | NSD2MAPTSMN1; SMN2ALOX5ALDH1A1 | |
| SCHEMBL11579444 | 0.77 | NSD2 (0.67) | NSD2MAPTSMN1; SMN2ALOX5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5674968-A | Aromatic sulfonated diester monomer, process to synthesize, polymer derived therefrom and method to prepare said polymer | THE DOW CHEMICAL COMPANY (US) | 1997-10-07 | — | — | US | claimed |
| US-5807962-A | POLYCARBONATES; SOLVENT RESISTANCE; FIREPROOFING | THE DOW CHEMICAL COMPANY (US) | 1998-09-15 | — | — | US | disclosed |
| US-5807962-A | POLYCARBONATES; SOLVENT RESISTANCE; FIREPROOFING | THE DOW CHEMICAL COMPANY (US) | 1998-09-15 | — | — | US | disclosed |
| US-5674968-A | Aromatic sulfonated diester monomer, process to synthesize, polymer derived therefrom and method to prepare said polymer | THE DOW CHEMICAL COMPANY (US) | 1997-10-07 | — | — | US | disclosed |