Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 19/20 | 0.81 |
| ▸ | GPR68 | Q15743 | 1/20 | 0.54 |
| ▸ | TPH2 | Q8IWU9 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869853 | 1.00 | TPH1 (0.81) | TPH1GPR68TPH2 | |
| SCHEMBL2733449 | 0.86 | TPH1 (0.76) | TPH1 | |
| SCHEMBL2733448 | 0.86 | TPH1 (0.76) | TPH1 | |
| SCHEMBL309002 | 0.84 | TPH1 (1.00) | TPH1 | |
| SCHEMBL307395 | 0.84 | TPH1 (1.00) | TPH1 | |
| SCHEMBL869851 | 0.80 | TPH1 (0.56) | TPH1TPH2 | |
| SCHEMBL20274801 | 0.76 | TPH1 (0.70) | TPH1 | |
| SCHEMBL1869972 | 0.76 | TPH1 (0.60) | TPH1 | |
| SCHEMBL1873079 | 0.76 | TPH1 (0.83) | TPH1 | |
| Benzoguanamine SCHEMBL21351508 | 0.74 | TPH1 (0.71) | TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054308-A1 | Methods and Compositions for Treating Pulmonary Hypertension and Related Diseases and Disorders | TERSERA THERAPEUTICS LLC | 2009-02-26 | — | — | US | claimed |
| US-20070191370-A1 | Multicyclic amino acid derivatives and methods of their use | TERSERA THERAPEUTICS LLC | 2007-08-16 | — | — | US | claimed |
| EP-2386547-B1 | Multicyclic amino acid derivatives and methods of their use | LEXICON PHARMACEUTICALS INC (US) | 2018-06-20 | — | — | EP | disclosed |
| US-9717727-B2 | Methods of treating and preventing leukemia and other cancers of the blood and bone | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-08-01 | — | — | US | disclosed |
| US-20140303197-A1 | METHODS OF TREATING AND PREVENTING LEUKEMIA AND OTHER CANCERS OF THE BLOOD AND BONE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-10-09 | — | — | US | disclosed |
| WO-2014082034-A1 | METHODS FOR TREATING IRRITABLE BOWEL SYNDROME | LEXICON PHARMACEUTICALS, INC. (US) | 2014-05-30 | — | — | WO | disclosed |
| US-20130303763-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NECROTIZING ENTEROCOLITIS | LEXICON PHARMACEUTICALS, INC. | 2013-11-14 | — | — | US | disclosed |
| WO-2013148978-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NECROTIZING ENTEROCOLITIS | LEXICON PHARMACEUTICALS, INC. (US) | 2013-10-03 | — | — | WO | disclosed |
| EP-2504008-A1 | METHODS AND ASSAYS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME | Lexicon Pharmaceuticals, Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| US-20120077831-A1 | METHODS AND ASSAYS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME | LEXICON PHARMACEUTICALS, INC. | 2012-03-29 | — | — | US | disclosed |
| EP-2386547-A1 | Multicyclic amino acid derivatives and methods of their use | Lexicon Pharmaceuticals, Inc. (US) | 2011-11-16 | — | — | EP | disclosed |
| US-8039086-B2 | Bonding material, process for producing the same, and honeycomb structure made with the same | NGK INSULATORS, LTD. (JP) | 2011-10-18 | — | — | US | disclosed |
| US-20110124667-A1 | METHODS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME | LEXICON PHARMACEUTICALS, INC. | 2011-05-26 | — | — | US | disclosed |
| WO-2011063181-A1 | METHODS AND ASSAYS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME | LEXICON PHARMACEUTICALS, INC. (US) | 2011-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054308-A1 | Methods and Compositions for Treating Pulmonary Hypertension and Related Diseases and Disorders | TPH1, PAH, TPH2 | TPH1 1/4885GPR68 1609/4885TPH2 3/4885 |
| US-20120077831-A1 | METHODS AND ASSAYS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME | SI, HNMT, ALPI | TPH1 65/4885GPR68 660/4885TPH2 50/4885 |
| US-20070191370-A1 | Multicyclic amino acid derivatives and methods of their use | AADAT, HNMT, TPH1 | TPH1 3/4885GPR68 1400/4885TPH2 4/4885 |
| US-20110124667-A1 | METHODS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME | SI, HNMT, SLC10A2 | TPH1 85/4885GPR68 617/4885TPH2 63/4885 |
| US-20140303197-A1 | METHODS OF TREATING AND PREVENTING LEUKEMIA AND OTHER CANCERS OF THE BLOOD AND BONE | TPH1, TPH2, HNMT | TPH1 1/4885GPR68 2758/4885TPH2 2/4885 |
| US-20130303763-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NECROTIZING ENTEROCOLITIS | TPH1, TPH2, VIP | TPH1 1/4885GPR68 1400/4885TPH2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.