Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | PKLR | P30613 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8709039 | 0.93 | BCL9 (0.40) | MAPTSMN1; SMN2KAT6ATP53NAMPT | |
| SCHEMBL8709884 | 0.92 | MAPT (0.41) | MAPTSMN1; SMN2TP53NAMPTPPARG | |
| SCHEMBL8709447 | 0.86 | ITGB3 (0.48) | MAPTSMN1; SMN2MMP2MMP9ITGB3 | |
| SCHEMBL8709683 | 0.85 | ITGB3 (0.43) | MAPTITGB3ITGAVPKLRMEN1 | |
| SCHEMBL8712032 | 0.84 | SLC7A5 (0.43) | MAPTSMN1; SMN2KAT6ANAMPTITGB3 | |
| SCHEMBL8706028 | 0.84 | MAPT (0.41) | MAPTSMN1; SMN2ITGB3ITGAVMEN1 | |
| SCHEMBL8714137 | 0.84 | TARS1 (0.45) | MAPTMMP2MMP9ITGB3ITGAV | |
| SCHEMBL8705122 | 0.83 | HTR6 (0.45) | MAPTITGB3ITGAVPKLRMEN1 | |
| SCHEMBL8709162 | 0.83 | MAPT (0.45) | MAPTSMN1; SMN2TP53MMP2MMP9 | |
| SCHEMBL8711019 | 0.82 | MAPT (0.43) | MAPTSMN1; SMN2NAMPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998041515-A1 | ENDOTHOLIN RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 1998-09-24 | — | — | WO | disclosed |