Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.44 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8709808 | 0.79 | CSNK2A1 (0.50) | SMN1; SMN2ALDH1A1HPGDCYP1A2KDM4E | |
| SCHEMBL8712176 | 0.77 | GSTA1 (0.63) | ALDH1A1HPGDCYP1A2KDM4EMEN1 | |
| SCHEMBL8711999 | 0.75 | TRPA1 (0.42) | GRM4HPGDCYP1A2KDM4ENPC1 | |
| SCHEMBL8709049 | 0.75 | MAPT (0.53) | SMN1; SMN2ALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL8654976 | 0.75 | FTO (0.45) | KDM4DKDM4CKDM3AALDH1A1KDM4E | |
| SCHEMBL30621955 | 0.74 | SMN1; SMN2 (0.57) | KDM4CSMN1; SMN2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL925741 | 0.74 | SMN1; SMN2 (0.57) | KDM4CSMN1; SMN2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL8709073 | 0.74 | KDM4E (0.50) | SMN1; SMN2ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL8714018 | 0.73 | KDM4E (0.43) | ALDH1A1HPGDCYP1A2KDM4EMEN1 | |
| SCHEMBL170522 | 0.73 | KDM4C (0.62) | KDM5AKDM4DKDM4CKDM5BKDM3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |