Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | CIT | O14578 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873706 | 0.91 | PFKFB2 (0.42) | SCN3ASCN9AHDAC3HDAC4HDAC1 | |
| SCHEMBL873304 | 0.82 | PFKFB3 (0.39) | SCN3ASCN9ASCN5AHDAC3HDAC4 | |
| SCHEMBL10119595 | 0.82 | SCN3A (0.43) | SCN3ASCN9ASCN5AHDAC3HDAC4 | |
| SCHEMBL873223 | 0.79 | RHOC (0.43) | SCN3ASCN9AJAK2PDGFRBFLT3 | |
| SCHEMBL872815 | 0.77 | PSMB8 (0.38) | SCN3ASCN9ASCN5AHDAC3HDAC4 | |
| SCHEMBL845510 | 0.75 | SCN3A (0.54) | SCN3ASCN9AJAK2PDGFRBFLT3 | |
| SCHEMBL872886 | 0.74 | KDM4E (0.52) | PFKFB3PFKFB2PFKFB1 | |
| SCHEMBL10119687 | 0.73 | CYP2C9 (0.44) | HDAC8PSMB8PFKFB3PFKFB2PFKFB1 | |
| SCHEMBL845110 | 0.73 | ALDH1A1 (0.48) | PFKFB3PFKFB2PFKFB1 | |
| SCHEMBL10119294 | 0.72 | ITGB3 (0.41) | SCN3ASCN9AJAK2PDGFRBFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |