SCHEMBL8723006

SCHEMBL8723006

C[C@H](NC(=O)c1ccc(Cc2ccc(N(CCBr)CCBr)cc2)cc1)C(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(=O)OC(C)(C)C

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHFR P00374 3/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
CYP1A2 P05177 1/20 0.33
ALOX15 P16050 1/20 0.33
CYP2C19 P33261 1/20 0.33
PTGS2 P35354 1/20 0.33
PPARG P37231 1/20 0.32
PPARA Q07869 1/20 0.32
P2RY12 Q9H244 2/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
CBX4 O00257 2/20 0.32
CBX7 O95931 2/20 0.32
CDYL2 Q8N8U2 2/20 0.32
CBX8 Q9HC52 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
TDP1 Q9NUW8 1/20 0.31
ATM Q13315 1/20 0.31
MMP2 P08253 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8726187 0.93 ADAMTS5 (0.36) DHFRP2RY12MMP2MMP8MMP12
SCHEMBL8721920 0.92 DHFR (0.34) DHFRALDH1A1LMNACYP1A2ALOX15
SCHEMBL8722967 0.85 ALDH1A1 (0.41) ALDH1A1LMNACYP1A2ALOX15CYP2C19
SCHEMBL8722966 0.85 ADAMTS5 (0.37) DHFRP2RY12CBX4CBX7CDYL2
SCHEMBL8726195 0.85 NPC1 (0.38) ALDH1A1LMNACYP1A2ALOX15CYP2C19
SCHEMBL8726175 0.84 ADAMTS5 (0.36) DHFRP2RY12MMP2MMP8MMP12
SCHEMBL8724180 0.81 CA2 (0.45) DHFR
SCHEMBL8726513 0.79 MAPT (0.42) PPARGPPARATDP1
SCHEMBL9751830 0.79 EGFR (0.45) DHFRLMNAP2RY12HDAC6
SCHEMBL8726173 0.78 NOD2 (0.33) DHFRP2RY12CBX4CBX7CDYL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998035982-A1 COMPOUNDS FOR USE IN ADEPT ZENECA LIMITED (GB) 1998-08-20 WO disclosed