Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Phthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA4 | P22748 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CDC25B | P30305 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalic Acid SCHEMBL28252362 | 1.00 | ALDH1A1 (0.70) | ALDH1A1ALOX15AKR1C3KDM4EHPGD | |
| Phthalic Acid SCHEMBL183234 | 1.00 | ALDH1A1 (0.70) | ALDH1A1ALOX15AKR1C3KDM4EHPGD | |
| Phthalic Acid SCHEMBL27513238 | 1.00 | ALDH1A1 (0.70) | ALDH1A1ALOX15AKR1C3KDM4EHPGD | |
| Phthalic Acid SCHEMBL8168901 | 1.00 | ALDH1A1 (0.70) | ALDH1A1ALOX15AKR1C3KDM4EHPGD | |
| Phthalic Acid SCHEMBL588315 | 1.00 | ALDH1A1 (0.70) | ALDH1A1ALOX15AKR1C3KDM4EHPGD | |
| Phthalic Acid SCHEMBL3914685 | 1.00 | ALDH1A1 (0.70) | ALDH1A1ALOX15AKR1C3KDM4EHPGD | |
| Phthalic Acid SCHEMBL27618570 | 1.00 | ALDH1A1 (0.70) | ALDH1A1ALOX15AKR1C3KDM4EHPGD | |
| Phthalic Acid SCHEMBL29397108 | 1.00 | ALDH1A1 (0.70) | ALDH1A1ALOX15AKR1C3KDM4EHPGD | |
| Phthalic Acid SCHEMBL1930940 | 1.00 | ALDH1A1 (0.70) | ALDH1A1ALOX15AKR1C3KDM4EHPGD | |
| Phthalic Acid SCHEMBL28014351 | 1.00 | ALDH1A1 (0.70) | ALDH1A1ALOX15AKR1C3KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5714093-A | THIXOTROPIC GEL CONSISTS OF ALKALI SILICATE AND A CARRIER COMPRISING POLYALPHA OLEFIN | ELISHA TECHNOLOGIES CO. L.L.C. (US) | 1998-02-03 | — | — | US | disclosed |