Sugi Predict

Sugi Predict / Compounds / SCHEMBL8736741

SCHEMBL8736741

SCHEMBL8736741

CSc1ccc(Sc2ccc(C)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 4/20 0.50
▸ KMT2A Q03164 4/20 0.50
▸ MAPT P10636 3/20 0.50
▸ NPC1 O15118 3/20 0.50
▸ RAB9A P51151 3/20 0.50
▸ ALDH1A1 P00352 3/20 0.47
▸ ALOX12 P18054 1/20 0.47
▸ MLYCD O95822 1/20 0.47
▸ TDP1 Q9NUW8 2/20 0.44
▸ ACHE P22303 1/20 0.44
▸ HKDC1 Q2TB90 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43
▸ L3MBTL1 Q9Y468 1/20 0.43
▸ HAO1 Q9UJM8 1/20 0.42
▸ BCL2 P10415 1/20 0.41
▸ MCL1 Q07820 1/20 0.41
▸ TSHR P16473 2/20 0.40
▸ MAPK1 P28482 2/20 0.40
▸ LMNA P02545 1/20 0.40
▸ NR1H2 P55055 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25723788 1.00 MEN1 (0.50) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL17552842 0.93 MLYCD (0.47) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL19107726 0.93 MEN1 (0.46) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL17914390 0.93 MEN1 (0.46) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL76792 0.91 — —
Hydrochloric Acid SCHEMBL7990919 0.88 MEN1 (0.54) MEN1KMT2AMAPTNPC1RAB9A
Water SCHEMBL27813433 0.88 MEN1 (0.54) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL12245875 0.88 ACHE (0.57) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL7033576 0.88 ALDH1A1 (0.50) ALDH1A1L3MBTL1TSHRMAPK1LMNA
SCHEMBL83853 0.88 ACHE (0.57) MEN1KMT2AMAPTNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230303839-A1 Polymer Composition with a High Degree of Thermal Shock Resistance TICONA LLC 2023-09-28 — — US disclosed
US-20230203271-A1 EMI Shielding Polymer Composition TICONA LLC 2023-06-29 — — US disclosed
US-9994679-B2 Polymerization process of polyarylene sulfide INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2018-06-12 — — US disclosed
EP-2836552-B1 POLYARYLENE SULFIDE COMPONENTS FOR AUTOMOTIVE APPLICATIONS TICONA LLC (US) 2018-04-25 — — EP disclosed
US-9790323-B2 Polymer conductor for lithium-ion batteries THE PENN STATE RESEARCH FOUNDATION (US) 2017-10-17 — — US disclosed
US-9790323-B2 Polymer conductor for lithium-ion batteries THE PENN STATE RESEARCH FOUNDATION (US) 2017-10-17 — — US disclosed
US-20170204225-A1 POLYMERIZATION PROCESS OF POLYARYLENE SULFIDE INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2017-07-20 — — US disclosed
US-20170197913-A1 METHOD FOR PREPARING POLYARYLENE SULFIDE (PAS) MONOMER INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2017-07-13 — — US disclosed
US-20170198141-A1 METHOD FOR PREPARING A POLYMER INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2017-07-13 — — US disclosed
US-20150218313-A1 Polymer Conductor for Lithium-Ion Batteries THE PENN STATE RESEARCH FOUNDATION 2015-08-06 — — US disclosed
US-20140335440-A1 MOLDED ARTICLE OF POLYMER ELECTROLYTE COMPOSITION AND SOLID POLYMER TYPE FUEL CELL USING SAME TORAY INDUSTRIES, INC. (JP) 2014-11-13 — — US disclosed
US-20120129893-A1 Inhibition Of Raf Kinase Using Substituted Heterocyclic Ureas DUMAS JACQUES (US) 2012-05-24 — — US disclosed
US-20120129893-A1 Inhibition Of Raf Kinase Using Substituted Heterocyclic Ureas DUMAS JACQUES (US) 2012-05-24 — — US disclosed
WO-2010136940-A1 NOVEL GLUCOCORTICOID RECEPTOR AGONISTS PFIZER LIMITED (GB) 2010-12-02 — — WO disclosed
US-20100303758-A1 Novel Glucocorticoid Receptor Agonists GLOSSOP PAUL ALAN 2010-12-02 — — US disclosed
US-7462672-B2 Polymer alloy TORAY INDUSTRIES, INC. (JP) 2008-12-09 — — US disclosed
US-20070244120-A1 INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS BAYER HEALTHCARE LLC 2007-10-18 — — US disclosed
US-20070244120-A1 INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS BAYER HEALTHCARE LLC 2007-10-18 — — US disclosed
US-20070225450-A1 Polymer alloy KOBAYASHI SADAYUKI 2007-09-27 — — US disclosed
US-7235612-B2 Polymer alloy and method for manufacturing polymer alloy TORAY INDUSTRIES, INC. (JP) 2007-06-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100303758-A1 Novel Glucocorticoid Receptor Agonists NR3C1, NR3C2, MC2R MEN1 3637/4885KMT2A 4072/4885MAPT 4146/4885
US-20170197913-A1 METHOD FOR PREPARING POLYARYLENE SULFIDE (PAS) MONOMER ARSA, TST, RRS1 MEN1 2180/4885KMT2A 2576/4885MAPT 4289/4885
US-20070244120-A1 INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS BRAF, RAF1, ARAF MEN1 2248/4885KMT2A 1462/4885MAPT 3056/4885
US-20150218313-A1 Polymer Conductor for Lithium-Ion Batteries TRPM8, TPR, EPCAM MEN1 1164/4885KMT2A 1778/4885MAPT 1017/4885
US-20120129893-A1 Inhibition Of Raf Kinase Using Substituted Heterocyclic Ureas BRAF, RAF1, ARAF MEN1 2248/4885KMT2A 1462/4885MAPT 3056/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.