⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744338 | 1.00 | — | — | |
| SCHEMBL8744432 | 0.75 | OPRM1 (0.33) | — | |
| SCHEMBL8744370 | 0.67 | NCF1 (0.35) | — | |
| SCHEMBL8744444 | 0.65 | ALOX15 (0.39) | — | |
| SCHEMBL8744397 | 0.64 | GNAO1 (0.50) | — | |
| SCHEMBL8744361 | 0.63 | ALOX15 (0.38) | — | |
| SCHEMBL26353640 | 0.62 | SIGMAR1 (0.34) | — | |
| SCHEMBL26353562 | 0.61 | SIGMAR1 (0.38) | — | |
| SCHEMBL26353220 | 0.61 | SIGMAR1 (0.38) | — | |
| SCHEMBL25633609 | 0.61 | SIGMAR1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614534-A | Derivatives of β, β-dimethyl-4-piperidineethanamine as inhibitors of the cholesterol biosynthesis | FOURNIER INDUSTRIE ET SANTE (FR) | 1997-03-25 | — | — | US | claimed |
| EP-0699187-B1 | BETA,BETA-DIMETHYL-4-PIPERIDINEETHANAMINE DERIVATIVES AS INHIBITORS OF THE CHOLESTEROL BIOSYNTHESIS | FOURNIER IND & SANTE (FR) | 1997-01-22 | — | — | EP | claimed |
| EP-0699187-A1 | DERIVATIVES OF -g(b), -g(b)-DIMETHYL-4-PIPERIDINEETHANAMINE AS INHIBITORS OF THE CHOLESTEROL BIOSYNTHESIS | FOURNIER IND & SANTE (FR) | 1996-03-06 | — | — | EP | claimed |
| WO-1994026713-A1 | DERIVATIVES OF β, β-DIMETHYL-4-PIPERIDINEETHANAMINE AS INHIBITORS OF THE CHOLESTEROL BIOSYNTHESIS | FOURNIER INDUSTRIE ET SANTE (FR) | 1994-11-24 | — | — | WO | claimed |
| US-5614534-A | Derivatives of β, β-dimethyl-4-piperidineethanamine as inhibitors of the cholesterol biosynthesis | FOURNIER INDUSTRIE ET SANTE (FR) | 1997-03-25 | — | — | US | disclosed |
| EP-0699187-B1 | BETA,BETA-DIMETHYL-4-PIPERIDINEETHANAMINE DERIVATIVES AS INHIBITORS OF THE CHOLESTEROL BIOSYNTHESIS | FOURNIER IND & SANTE (FR) | 1997-01-22 | — | — | EP | disclosed |
| EP-0699187-A1 | DERIVATIVES OF -g(b), -g(b)-DIMETHYL-4-PIPERIDINEETHANAMINE AS INHIBITORS OF THE CHOLESTEROL BIOSYNTHESIS | FOURNIER IND & SANTE (FR) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994026713-A1 | DERIVATIVES OF β, β-DIMETHYL-4-PIPERIDINEETHANAMINE AS INHIBITORS OF THE CHOLESTEROL BIOSYNTHESIS | FOURNIER INDUSTRIE ET SANTE (FR) | 1994-11-24 | — | — | WO | disclosed |