Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 5/20 | 0.38 |
| ▸ | USP8 | P40818 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744776 | 0.87 | LRRK2 (0.43) | USP8LRRK2ARTSHR | |
| SCHEMBL31218523 | 0.76 | TRPA1 (0.40) | LRRK2PRKDC | |
| SCHEMBL8744748 | 0.74 | IDO1 (0.41) | — | |
| SCHEMBL8744696 | 0.74 | L3MBTL1 (0.46) | LRRK2ADORA2A | |
| SCHEMBL8744753 | 0.73 | CTSS (0.49) | LRRK2ARADORA2ATSHR | |
| SCHEMBL7142089 | 0.72 | TNKS (0.39) | NUDT1ARTSHR | |
| SCHEMBL11048748 | 0.72 | NUDT1 (0.38) | NUDT1TLR8CNR2ARTSHR | |
| SCHEMBL27857839 | 0.71 | IDO1 (0.41) | LRRK2ARNISCH | |
| SCHEMBL8744742 | 0.70 | CYP11B1 (0.43) | LRRK2ADORA2A | |
| SCHEMBL25357822 | 0.70 | USP8 (0.38) | USP8LRRK2ARTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653421-B1 | Process for preparing 2-cyanoimidazole compounds | ISHIHARA SANGYO KAISHA (JP) | 1997-01-15 | — | — | EP | disclosed |
| US-5552557-A | Process for preparing 2-cyanoimidazole compounds by reaction of an amino ketone compound | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1996-09-03 | — | — | US | disclosed |
| EP-0653421-A1 | Process for preparing 2-cyanoimidazole compounds | ISHIHARA SANGYO KAISHA LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |