SCHEMBL8744742

SCHEMBL8744742

Cc1ccc(-c2c[nH]c(C#N)n2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 1/20 0.43
CYP11B2 P19099 1/20 0.43
ERBB2 P04626 1/20 0.41
KDM4E B2RXH2 6/20 0.40
ADORA1 P30542 4/20 0.40
ADORA2A P29274 3/20 0.40
NPSR1 Q6W5P4 3/20 0.40
HPGD P15428 2/20 0.40
LRRK2 Q5S007 1/20 0.40
PPARG P37231 1/20 0.40
NCOA2 Q15596 1/20 0.40
NCOA1 Q15788 1/20 0.40
NCOA3 Q9Y6Q9 1/20 0.40
METAP2 P50579 1/20 0.38
METAP1 P53582 1/20 0.38
ALDH1A1 P00352 4/20 0.38
CYP2A6 P11509 1/20 0.38
ENPP3 O14638 1/20 0.37
ENPP1 P22413 1/20 0.37
GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8744832 0.82 MCL1 (0.42) CYP11B1CYP11B2KDM4EADORA1ADORA2A
SCHEMBL8744752 0.82 ERBB2 (0.41) ERBB2KDM4EADORA1ADORA2ANPSR1
SCHEMBL8744743 0.82 MCL1 (0.41) ERBB2KDM4EADORA1ADORA2ANPSR1
SCHEMBL7432291 0.81 ADORA2A (0.41) CYP11B1CYP11B2ERBB2KDM4EADORA1
SCHEMBL8744692 0.81 CYP2A6 (0.43) KDM4EHPGDMETAP2ALDH1A1CYP2A6
SCHEMBL8744753 0.81 CTSS (0.49) KDM4EADORA1ADORA2AHPGDLRRK2
SCHEMBL8744693 0.80 CCNC (0.47) ADORA1ADORA2AMAPTCYP1A2CYP3A4
SCHEMBL8744687 0.78 KIF11 (0.47) KDM5A
SCHEMBL9876232 0.76 MAPT (0.43) ALDH1A1MAPTMEN1KMT2ANPC1
SCHEMBL8250696 0.75 METAP2 (0.44) KDM4EHPGDMETAP2METAP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115768517-B Antimicrobial agent for non-human animals 石原产业株式会社 2024-08-16 CN claimed
CN-115996714-A Antifungal agent for human use 石原产业株式会社 2023-04-21 CN claimed
CN-115768517-A Antibacterial agent for non-human animals 石原产业株式会社 2023-03-07 CN claimed
CN-107118160-B A kind of preparation process of the chloro- 1H- imidazoles of 2- cyano -4- (p-methylphenyl) -5- 盐城辉煌化工有限公司 2019-06-28 CN claimed
CN-115768517-B Antimicrobial agent for non-human animals 石原产业株式会社 2024-08-16 CN disclosed
US-20230255939-A1 Antimicrobial Agent for Non-Human Animal ISHIHARA SANGYO KAISHA, LTD. (JP) 2023-08-17 US disclosed
CN-115996714-A Antifungal agent for human use 石原产业株式会社 2023-04-21 CN disclosed
CN-115768517-A Antibacterial agent for non-human animals 石原产业株式会社 2023-03-07 CN disclosed
CN-110337434-B Process for preparing 2-cyanoimidazole compounds 安道麦马克西姆有限公司 2022-11-22 CN disclosed
CN-107118160-B A kind of preparation process of the chloro- 1H- imidazoles of 2- cyano -4- (p-methylphenyl) -5- 盐城辉煌化工有限公司 2019-06-28 CN disclosed
CN-107118160-B A kind of preparation process of the chloro- 1H- imidazoles of 2- cyano -4- (p-methylphenyl) -5- 盐城辉煌化工有限公司 2019-06-28 CN disclosed
CN-108760920-A A method of cyazofamid and its metabolite residue amount are measured based on HPLC-MSMS methods 山东省农药科学研究院 2018-11-06 CN disclosed
EP-0653421-B1 Process for preparing 2-cyanoimidazole compounds ISHIHARA SANGYO KAISHA (JP) 1997-01-15 EP disclosed
US-5552557-A Process for preparing 2-cyanoimidazole compounds by reaction of an amino ketone compound ISHIHARA SANGYO KAISHA, LTD. (JP) 1996-09-03 US disclosed
EP-0653421-A1 Process for preparing 2-cyanoimidazole compounds ISHIHARA SANGYO KAISHA LTD. (JP) 1995-05-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230255939-A1 Antimicrobial Agent for Non-Human Animal Q6ZSR9, SPTAN1, MPO CYP11B1 4051/4885CYP11B2 3713/4885ERBB2 4598/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.