Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 3/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874117 | 0.78 | RAB9A (0.48) | SMN1; SMN2KDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL874301 | 0.74 | ALDH1A1 (0.40) | ALDH1A1MAPTRAB9AKMT2ANPC1 | |
| SCHEMBL10820841 | 0.70 | ALDH1A1 (0.53) | SMN1; SMN2KDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL4497703 | 0.70 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL874267 | 0.69 | ALDH1A1 (0.39) | SMN1; SMN2KDM4EALDH1A1RAB9AGAA | |
| SCHEMBL873941 | 0.67 | RAB9A (0.48) | SMN1; SMN2KDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL6228168 | 0.67 | ALDH1A1 (0.67) | SMN1; SMN2KDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL3436651 | 0.66 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL6249569 | 0.65 | NFKB1 (0.39) | SMN1; SMN2KDM4EALDH1A1RAB9ACDC7 | |
| SCHEMBL6183496 | 0.65 | ACHE (0.66) | KDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |