Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL482717 | 0.83 | TRPV4 (0.45) | TRPV4ADRB1 | |
| SCHEMBL26294995 | 0.79 | IDH1 (0.33) | TRPV4ADRB1 | |
| SCHEMBL28173201 | 0.75 | SORT1 (0.36) | ADRB1 | |
| SCHEMBL2014949 | 0.75 | GABRA1 (0.38) | ADRB1 | |
| SCHEMBL31525410 | 0.74 | SYK (0.38) | — | |
| SCHEMBL18581 | 0.71 | LMNA (0.38) | — | |
| SCHEMBL30423979 | 0.71 | MBOAT4 (0.32) | — | |
| SCHEMBL28173219 | 0.70 | CYP19A1 (0.43) | — | |
| SCHEMBL29628255 | 0.70 | CYP19A1 (0.43) | — | |
| SCHEMBL17329 | 0.68 | SDHB (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684011-A | Pyrimidine derivatives useful as nematicides | ZENECA LIMITED (GB) | 1997-11-04 | — | — | US | disclosed |
| EP-0660827-B1 | HETEROCYCLIC COMPOUNDS WITH PARASITICAL ACTIVITY | ZENECA LTD (GB) | 1997-04-16 | — | — | EP | disclosed |
| EP-0660827-A1 | HETEROCYCLIC COMPOUNDS WIHT PARASITICAL ACTIVITY. | ZENECA LTD (GB) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006777-A1 | HETEROCYCLIC COMPOUNDS WIHT PARASITICAL ACTIVITY | ZENECA LIMITED (GB) | 1994-03-31 | — | — | WO | disclosed |