Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TNF | P01375 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
| ▸ | FLI1 | Q01543 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447238 | 0.89 | TNF (0.48) | HAO1MMP2MMP9MMP8SMN1; SMN2 | |
| SCHEMBL8766483 | 0.78 | GSR (0.47) | MMP2MMP9MMP8SMN1; SMN2RAB9A | |
| SCHEMBL8766778 | 0.77 | RAB9A (0.41) | SMN1; SMN2ALDH1A1TSHRRAB9AMAPT | |
| SCHEMBL8766562 | 0.74 | L3MBTL1 (0.50) | SMN1; SMN2ALDH1A1TNFMAPK1RAB9A | |
| SCHEMBL24634980 | 0.74 | PKM (0.56) | SMN1; SMN2ALDH1A1TSHRMAPK1RAB9A | |
| SCHEMBL5739984 | 0.71 | RAB9A (0.69) | SMN1; SMN2ALDH1A1TSHRMAPK1RAB9A | |
| SCHEMBL5738542 | 0.71 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1TSHRRAB9AMAPT | |
| SCHEMBL5739537 | 0.71 | RAB9A (0.69) | SMN1; SMN2ALDH1A1TSHRMAPK1RAB9A | |
| SCHEMBL10418997 | 0.70 | HTT (0.63) | SMN1; SMN2ALDH1A1TSHRRAB9AMAPT | |
| SCHEMBL29236547 | 0.70 | GSK3B (0.66) | MMP2MMP9SMN1; SMN2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | claimed |
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | disclosed |