Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8766778 | 0.78 | RAB9A (0.41) | LMNARAB9ASMN1; SMN2HTTMAPT | |
| SCHEMBL8766644 | 0.78 | HAO1 (0.43) | MMP2MMP9MMP8LMNARAB9A | |
| SCHEMBL8767909 | 0.75 | L3MBTL1 (0.49) | LMNASMN1; SMN2 | |
| SCHEMBL24634980 | 0.73 | PKM (0.56) | LMNARAB9ASMN1; SMN2HTTMAPT | |
| SCHEMBL1185872 | 0.70 | GSR (0.61) | GSRMMP2MMP9MMP8SMN1; SMN2 | |
| SCHEMBL5058142 | 0.70 | GSR (0.61) | GSRMMP2MMP9MMP8 | |
| SCHEMBL5739537 | 0.70 | RAB9A (0.69) | LMNARAB9ASMN1; SMN2HTTMAPT | |
| SCHEMBL5739984 | 0.70 | RAB9A (0.69) | RAB9ASMN1; SMN2HTTMAPTKMT2A | |
| SCHEMBL5738542 | 0.70 | ALDH1A1 (0.54) | LMNARAB9ASMN1; SMN2HTTMAPT | |
| SCHEMBL8444585 | 0.70 | POLB (0.63) | LMNAHTTMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | disclosed |