Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 5/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8106135 | 0.91 | LMNA (0.40) | LMNAHPGDHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL8767162 | 0.90 | LMNA (0.40) | LMNAHPGDHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL8767144 | 0.87 | LMNA (0.38) | LMNAHPGDHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL8918674 | 0.85 | EGLN1 (0.46) | LMNAHPGDHTTSMN1; SMN2 | |
| SCHEMBL8768258 | 0.83 | CA1 (0.39) | EGFRLIMK1LIMK2PTGS2P4HTM | |
| SCHEMBL8097664 | 0.82 | ABL1 (0.37) | LMNAHPGDHTTSMN1; SMN2EGFR | |
| SCHEMBL9235404 | 0.80 | MAPT (0.46) | HTTSMN1; SMN2EGFRPTGS2PTGS1 | |
| SCHEMBL8096944 | 0.80 | SMN1; SMN2 (0.39) | LMNAHPGDHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL8916746 | 0.79 | EGLN1 (0.42) | LMNAHPGDHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL8099449 | 0.78 | LMNA (0.37) | LMNAHPGDHTTSMN1; SMN2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673931-B1 | Sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AG (DE) | 1997-08-13 | — | — | EP | disclosed |
| EP-0673931-A1 | Sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-27 | — | — | EP | disclosed |