Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.42 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774856 | 0.94 | SMN1; SMN2 (0.47) | LMNAL3MBTL1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL8774425 | 0.92 | RAB9A (0.46) | LMNAL3MBTL1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL8774190 | 0.88 | ALDH1A1 (0.51) | LMNAL3MBTL1SMN1; SMN2MAPTSLC5A1 | |
| SCHEMBL8774683 | 0.84 | RAB9A (0.40) | SMN1; SMN2CSNK2A1MAPTALDH1A1NPSR1 | |
| SCHEMBL1007733 | 0.82 | LMNA (0.42) | LMNAL3MBTL1SMN1; SMN2HTTCSNK2A1 | |
| SCHEMBL8774663 | 0.81 | SMN1; SMN2 (0.45) | LMNAL3MBTL1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL8774499 | 0.81 | TAAR1 (0.39) | LMNAL3MBTL1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL9154059 | 0.80 | LMNA (0.50) | LMNAL3MBTL1SMN1; SMN2HTTMAPT | |
| SCHEMBL8774662 | 0.80 | RAB9A (0.46) | LMNAL3MBTL1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL8774496 | 0.79 | RAB9A (0.49) | LMNAL3MBTL1SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |