Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NQO1 | P15559 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.40 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774856 | 0.88 | SMN1; SMN2 (0.47) | ALDH1A1LMNAMAPTL3MBTL1RAB9A | |
| SCHEMBL8774078 | 0.88 | LMNA (0.47) | ALDH1A1LMNAPOLBMAPTL3MBTL1 | |
| SCHEMBL8774425 | 0.85 | RAB9A (0.46) | ALDH1A1LMNAMAPTL3MBTL1RAB9A | |
| SCHEMBL8774499 | 0.83 | TAAR1 (0.39) | ALDH1A1LMNAMAPTL3MBTL1RAB9A | |
| SCHEMBL8774683 | 0.83 | RAB9A (0.40) | ALDH1A1POLBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8774663 | 0.81 | SMN1; SMN2 (0.45) | ALDH1A1LMNAPOLBMAPTL3MBTL1 | |
| SCHEMBL8774662 | 0.79 | RAB9A (0.46) | ALDH1A1LMNAMAPTL3MBTL1RAB9A | |
| SCHEMBL9154338 | 0.79 | RAB9A (0.50) | ALDH1A1LMNAMAPTL3MBTL1RAB9A | |
| SCHEMBL8774722 | 0.78 | ALDH1A1 (0.53) | ALDH1A1LMNAPOLBMAPTL3MBTL1 | |
| SCHEMBL28616323 | 0.77 | NQO1 (0.74) | LMNASMN1; SMN2NQO1GPR84SLC5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |