Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.35 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | PPIA | P62937 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779168 | 0.90 | SMN1; SMN2 (0.40) | PPIAKMT2ATP53SMN1; SMN2LMNA | |
| SCHEMBL8779406 | 0.85 | LTA4H (0.44) | PLAUSGMS2LTA4HPPIALRRK2 | |
| SCHEMBL8779187 | 0.84 | MRGPRX4 (0.37) | PPIAPTGER1LRRK2ALDH1A1 | |
| SCHEMBL8779134 | 0.84 | CARM1 (0.38) | PLAUANO1SGMS2LTA4HPTGER1 | |
| SCHEMBL8779285 | 0.83 | KDM4E (0.40) | KMT2ASMN1; SMN2LMNAALDH1A1RAB9A | |
| SCHEMBL8883967 | 0.82 | ANO1 (0.38) | PLAUANO1SGMS2JAK2TYK2 | |
| SCHEMBL8779246 | 0.82 | MAOB (0.43) | PPIAALDH1A1 | |
| SCHEMBL8779326 | 0.80 | SMN1; SMN2 (0.39) | KMT2ASMN1; SMN2LMNAHPGD | |
| SCHEMBL8779269 | 0.80 | L3MBTL1 (0.46) | PPIAALDH1A1 | |
| SCHEMBL8779331 | 0.79 | MMP1 (0.41) | KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |