Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 3/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 3/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779225 | 0.86 | PARP15 (0.40) | ACACBKMOIRAK4 | |
| SCHEMBL8786891 | 0.85 | MKNK1 (0.39) | ACACBLOXLOXL2PDE4DMKNK1 | |
| SCHEMBL8779390 | 0.84 | NFE2L2 (0.38) | IDO1 | |
| SCHEMBL8779175 | 0.83 | ACACB (0.41) | ACACBKMOPDE4DIRAK4PDE4A | |
| SCHEMBL8882242 | 0.82 | LOX (0.39) | ACACBLOXLOXL2KMOPDE4D | |
| SCHEMBL8779100 | 0.81 | LNPEP (0.42) | ACACBPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8779326 | 0.79 | SMN1; SMN2 (0.39) | ACACB | |
| SCHEMBL8779283 | 0.77 | ALDH1A1 (0.35) | IRAK4 | |
| SCHEMBL8779273 | 0.77 | IKBKB (0.38) | ACACB | |
| SCHEMBL8779237 | 0.76 | LOX (0.36) | ACACBLOXLOXL2MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661269-B1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0661269-A1 | Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-07-05 | — | — | EP | disclosed |