Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780776 | 0.93 | MAOA (0.37) | ADORA2APKMADORA3ADORA2BADORA1 | |
| SCHEMBL8780940 | 0.92 | ADORA2A (0.43) | ADORA2APKMADORA3ADORA2BADORA1 | |
| SCHEMBL8780789 | 0.85 | ADORA2A (0.41) | ADORA2APKMADORA3ADORA2BADORA1 | |
| SCHEMBL8780765 | 0.85 | KCNH2 (0.55) | PKMKCNH2ALDH1A1HPGD | |
| SCHEMBL8780867 | 0.85 | KCNH2 (0.43) | ADORA2APKMADORA3ADORA2BADORA1 | |
| SCHEMBL8781017 | 0.83 | NPC1 (0.48) | ADORA3KCNH2ACHEALDH1A1 | |
| SCHEMBL8780919 | 0.82 | HRH3 (0.41) | ADORA2APKMADORA3ADORA2BADORA1 | |
| SCHEMBL8780824 | 0.82 | TDP1 (0.39) | ADORA2APKMADORA3ADORA2BADORA1 | |
| SCHEMBL8780889 | 0.81 | SLC22A2 (0.40) | KCNH2MAPT | |
| SCHEMBL8780990 | 0.81 | KCNH2 (0.39) | ADORA2APKMADORA3ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697407-B1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS (JP) | 1997-06-25 | — | — | EP | disclosed |
| EP-0697407-A1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-02-21 | — | — | EP | disclosed |