Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780990 | 0.93 | KCNH2 (0.39) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL8780940 | 0.86 | ADORA2A (0.43) | KCNH2MCHR1PKMADORA3ADORA2A | |
| SCHEMBL8780824 | 0.85 | TDP1 (0.39) | KCNH2MCHR1PKMADORA3ADORA2A | |
| SCHEMBL8780815 | 0.85 | ADORA2A (0.38) | KCNH2ACHEMCHR1PKMADORA3 | |
| SCHEMBL8780872 | 0.84 | KCNH2 (0.63) | KCNH2PKMSIGMAR1HRH3SMN1; SMN2 | |
| SCHEMBL8780925 | 0.82 | KCNH2 (0.65) | KCNH2CACNA1FCHRM2ACHEAGTR1 | |
| SCHEMBL8780789 | 0.81 | ADORA2A (0.41) | KCNH2MCHR1PKMADORA3ADORA2A | |
| SCHEMBL8780781 | 0.81 | LTA4H (0.46) | KCNH2MCHR1SMN1; SMN2 | |
| SCHEMBL8780750 | 0.81 | TDP1 (0.37) | KCNH2MCHR1PKMADORA3ADORA2A | |
| SCHEMBL8780776 | 0.81 | MAOA (0.37) | KCNH2CHRM2ACHEDRD3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697407-B1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS (JP) | 1997-06-25 | — | — | EP | disclosed |
| EP-0697407-A1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-02-21 | — | — | EP | disclosed |