Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780808 | 0.86 | TAAR1 (0.45) | TAAR1SIGMAR1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL8780799 | 0.82 | KCNH2 (0.52) | TAAR1SMN1; SMN2 | |
| SCHEMBL8780856 | 0.81 | GRIN1 (0.50) | TAAR1SMN1; SMN2ALDH1A1HPGDLMNA | |
| SCHEMBL8780886 | 0.79 | CYP1A2 (0.47) | TAAR1ALDH1A1TSHRMAPK1 | |
| SCHEMBL8780893 | 0.77 | KCNH2 (0.59) | TAAR1SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL8780746 | 0.77 | TAAR1 (0.46) | TAAR1SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL8780755 | 0.74 | MAPK1 (0.47) | TAAR1ALDH1A1TSHRMAPK1 | |
| SCHEMBL8780906 | 0.73 | DRD2 (0.56) | TSHR | |
| SCHEMBL625373 | 0.73 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL10453660 | 0.71 | SIGMAR1 (0.91) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697407-B1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS (JP) | 1997-06-25 | — | — | EP | disclosed |
| EP-0697407-A1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-02-21 | — | — | EP | disclosed |