Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 4/20 | 0.46 |
| ▸ | MMP12 | P39900 | 4/20 | 0.46 |
| ▸ | MMP13 | P45452 | 4/20 | 0.46 |
| ▸ | MMP14 | P50281 | 4/20 | 0.46 |
| ▸ | MMP1 | P03956 | 3/20 | 0.46 |
| ▸ | MMP3 | P08254 | 3/20 | 0.46 |
| ▸ | MMP9 | P14780 | 3/20 | 0.46 |
| ▸ | MMP8 | P22894 | 3/20 | 0.46 |
| ▸ | MMP16 | P51512 | 3/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15207221 | 0.84 | ALDH1A1 (0.52) | ALDH1A1CYP3A4MAPK1MMP2MMP12 | |
| SCHEMBL10869745 | 0.81 | ALDH1A1 (0.68) | ALDH1A1CYP3A4MAPK1CNR2KDM4E | |
| SCHEMBL13401706 | 0.79 | MMP2 (0.75) | MMP2MMP12MMP13MMP14MMP1 | |
| SCHEMBL8788891 | 0.79 | HSD11B1 (0.45) | ALDH1A1HSD11B1 | |
| SCHEMBL2034446 | 0.76 | HSD11B1 (0.68) | ALDH1A1CYP3A4MAPK1CNR2KDM4E | |
| SCHEMBL8911211 | 0.76 | ALDH1A1 (0.60) | ALDH1A1CYP3A4MAPK1CNR2KDM4E | |
| SCHEMBL2947083 | 0.76 | ALDH1A1 (0.60) | ALDH1A1CYP3A4MAPK1CNR2KDM4E | |
| SCHEMBL22633432 | 0.74 | HTR2A (0.49) | ALDH1A1CYP3A4MAPK1MMP2MMP12 | |
| SCHEMBL7199480 | 0.74 | ALDH1A1 (0.62) | ALDH1A1CYP3A4MAPK1CNR2KDM4E | |
| SCHEMBL10395734 | 0.73 | ALDH1A1 (0.47) | ALDH1A1CYP3A4MAPK1CNR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468470-B1 | Benzimidazoles, medicaments containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-04-16 | — | — | EP | claimed |
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |