Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 3/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.45 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.45 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.45 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.45 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.45 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 4/20 | 0.42 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | CPN1 | P15169 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11698795 | 0.86 | GABRA5 (0.52) | GABRA5GABRB2SLC6A1SLC6A12SLC6A11 | |
| SCHEMBL8618756 | 0.84 | — | — | |
| SCHEMBL14204666 | 0.83 | GNAI3 (0.43) | GABRA5GABRB2SLC6A1SLC6A12SLC6A11 | |
| SCHEMBL24524829 | 0.80 | GABRA5 (0.47) | GABRA5GABRB2SLC6A1SLC6A12SLC6A11 | |
| SCHEMBL14751461 | 0.79 | — | — | |
| SCHEMBL327378 | 0.79 | KMT2A (0.43) | EPHX1TDP1 | |
| SCHEMBL26077271 | 0.78 | GABRA5 (0.45) | GABRA5GABRB2SLC6A1SLC6A12SLC6A11 | |
| SCHEMBL6264076 | 0.78 | GABRA5 (0.45) | GABRA5GABRB2SLC6A1SLC6A12SLC6A11 | |
| SCHEMBL4754506 | 0.77 | GABRA5 (0.48) | GABRA5GABRB2SLC6A1SLC6A12SLC6A11 | |
| SCHEMBL3846912 | 0.77 | HPGD (0.47) | EPHX1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174487-A1 | PHENYLPROPIONAMIDE COMPOUND AND USE THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2023-06-08 | — | — | US | disclosed |
| US-11091475-B2 | Methods and compositions for modulating splicing | SKYHAWK THERAPEUTICS, INC. (US) | 2021-08-17 | — | — | US | disclosed |
| US-20210171519-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. | 2021-06-10 | — | — | US | disclosed |
| US-20160362370-A1 | NUCLEAR RECEPTOR MODULATORS | ABBVIE INC. (US) | 2016-12-15 | — | — | US | disclosed |
| US-20160362370-A1 | NUCLEAR RECEPTOR MODULATORS | ABBVIE INC. (US) | 2016-12-15 | — | — | US | disclosed |
| US-9314468-B2 | Chemokine receptor modulators | ALTIRIS THERAPEUTICS, INC. (US) | 2016-04-19 | — | — | US | disclosed |
| US-20130172330-A1 | Chemokine Receptor Modulators | ALTIRIS THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| EP-1432707-B1 | AZABICYCLIC-SUBSTITUTED FUSED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN CO LLC (US) | 2012-03-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160362370-A1 | NUCLEAR RECEPTOR MODULATORS | NR1I2, NR1H2, NR5A2 | GABRA5 249/4885GABRB2 505/4885SLC6A1 2414/4885 |
| US-20210171519-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | RBM17, SF3B1, SNRPA1 | GABRA5 2677/4885GABRB2 1725/4885SLC6A1 4737/4885 |
| US-20230174487-A1 | PHENYLPROPIONAMIDE COMPOUND AND USE THEREOF | PAH, TRPV1, TRPA1 | GABRA5 815/4885GABRB2 1804/4885SLC6A1 423/4885 |
| US-20130172330-A1 | Chemokine Receptor Modulators | CCR5, CXCR4, ACKR3 | GABRA5 2939/4885GABRB2 2962/4885SLC6A1 2222/4885 |
| US-11091475-B2 | Methods and compositions for modulating splicing | RBM17, SF3B1, SNRPA1 | GABRA5 2677/4885GABRB2 1725/4885SLC6A1 4737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.