Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CASP2 | P42575 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9525258 | 0.81 | ALDH1A1 (0.56) | ALDH1A1CASP2SMN1; SMN2HTTMAPT | |
| SCHEMBL17536233 | 0.79 | ALDH1A1 (0.67) | ALDH1A1CASP2SMN1; SMN2HTTMAPT | |
| SCHEMBL1494291 | 0.79 | ALDH1A1 (0.79) | ALDH1A1SMN1; SMN2MAPTKMT2ANPC1 | |
| SCHEMBL1494383 | 0.79 | ALDH1A1 (0.56) | ALDH1A1CASP2SMN1; SMN2HTTMAPT | |
| SCHEMBL18485622 | 0.77 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HTTKMT2ANPSR1 | |
| SCHEMBL6939799 | 0.76 | P2RX7 (0.59) | ALDH1A1CASP2SMN1; SMN2HTTMAPT | |
| SCHEMBL3757797 | 0.76 | KMT2A (0.73) | ALDH1A1SMN1; SMN2HTTMAPTKMT2A | |
| SCHEMBL30021051 | 0.76 | TDP1 (0.61) | ALDH1A1CASP2SMN1; SMN2HTTMAPT | |
| SCHEMBL10895905 | 0.75 | AKR1C3 (0.59) | ALDH1A1SMN1; SMN2HTTMAPTKMT2A | |
| SCHEMBL22897585 | 0.74 | ALDH1A1 (0.51) | ALDH1A1CASP2SMN1; SMN2HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130237530-A1 | BENZODIAZEPINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING COGNITIVE IMPAIRMENT | AGENEBIO, INC. (US) | 2013-09-12 | — | — | US | disclosed |
| WO-2012068149-A1 | BENZODIAZEPINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING COGNITIVE IMPAIRMENT | AGENEBIO, INC. (US) | 2012-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130237530-A1 | BENZODIAZEPINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING COGNITIVE IMPAIRMENT | GABRA5, GABRA3, GABRB3 | ALDH1A1 2236/4885CASP2 2425/4885SMN1; SMN2 3677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.