Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215991 | 1.00 | ECE1 (0.34) | ECE1CYP19A1ALDH1A1FAAHMAPK1 | |
| SCHEMBL8832733 | 0.84 | FAAH (0.34) | ECE1CYP19A1ALDH1A1FAAHKDM4E | |
| SCHEMBL8833257 | 0.83 | FKBP1A (0.34) | ECE1CYP19A1FAAHMGLLFKBP1A | |
| SCHEMBL8833468 | 0.82 | SIGMAR1 (0.33) | ECE1SIGMAR1 | |
| SCHEMBL8833492 | 0.81 | ECE1 (0.37) | ECE1CYP19A1ALDH1A1FAAHKDM4E | |
| SCHEMBL9215980 | 0.81 | ECE1 (0.37) | ECE1CYP19A1ALDH1A1FAAHKDM4E | |
| SCHEMBL8832726 | 0.80 | LMNA (0.36) | CYP19A1ALDH1A1FAAHMAPK1HSD11B1 | |
| SCHEMBL9027366 | 0.80 | ECE1 (0.33) | ECE1CYP19A1SIGMAR1 | |
| SCHEMBL9210982 | 0.80 | LMNA (0.36) | CYP19A1ALDH1A1FAAHMAPK1HSD11B1 | |
| SCHEMBL9220659 | 0.78 | ECE1 (0.30) | ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5608056-A | Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0636133-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021186-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-28 | — | — | WO | disclosed |