Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | ALOX15B | O15296 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27736893 | 0.75 | ICMT (0.46) | CYP3A4L3MBTL1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11264432 | 0.73 | ICMT (0.45) | CYP3A4L3MBTL1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8865490 | 0.73 | HSD17B10 (0.47) | CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13117192 | 0.71 | ICMT (0.46) | CYP3A4L3MBTL1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7457735 | 0.69 | LPO (0.39) | ALDH1A1MEN1KMT2A | |
| SCHEMBL25421724 | 0.66 | L3MBTL1 (0.35) | CYP3A4L3MBTL1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11840250 | 0.66 | LMNA (0.55) | CYP1A2CYP2C9CYP2C19SMN1; SMN2NPC1 | |
| SCHEMBL353826 | 0.65 | CYP3A4 (0.50) | CYP3A4L3MBTL1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL5173638 | 0.65 | FDPS (0.47) | CYP3A4L3MBTL1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1407881 | 0.65 | CYP3A4 (0.46) | CYP3A4L3MBTL1CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5604224-A | NEURODEGENERATIVE DISORDERS | STERLING WINTHROP INC. (US) | 1997-02-18 | — | — | US | disclosed |
| US-5569655-A | Substituted heterocyclylisoquinolinium salts and compositions and method of use thereof | STERLING WINTHROP INC. (US) | 1996-10-29 | — | — | US | disclosed |
| EP-0647641-A1 | Substituted heterocyclylisoquinolinium salts and compositions and methods of usethereof | STERLING WINTHROP INC. (US) | 1995-04-12 | — | — | EP | disclosed |