SCHEMBL887635

SCHEMBL887635

O=C(O)/C=C/c1cn(C2CC(O)C(CO)O2)c(=O)[nH]c1=O

nearest known ligand 0.77

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TK1 P04183 3/20 0.77
CYP1A2 P05177 1/20 0.77
CYP3A4 P08684 1/20 0.77
TSHR P16473 1/20 0.77
BLM P54132 1/20 0.77
PMP22 Q01453 1/20 0.77
NPSR1 Q6W5P4 1/20 0.77
LMNA P02545 2/20 0.64
SMN1; SMN2 Q16637 2/20 0.64
ALOX12 P18054 1/20 0.60
ADRA1A P35348 1/20 0.60
TK2 O00142 1/20 0.59
TYMS P04818 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21316832 1.00 TK1 (0.77) TK1CYP1A2CYP3A4TSHRBLM
SCHEMBL887786 1.00 TK1 (0.77) TK1CYP1A2CYP3A4TSHRBLM
SCHEMBL5982137 1.00 TK1 (0.77) TK1CYP1A2CYP3A4TSHRBLM
SCHEMBL2922785 1.00 TK1 (0.77) TK1CYP1A2CYP3A4TSHRBLM
SCHEMBL13030268 1.00 TK1 (0.77) TK1CYP1A2CYP3A4TSHRBLM
SCHEMBL887788 1.00 TK1 (0.77) TK1CYP1A2CYP3A4TSHRBLM
SCHEMBL535679 1.00 TK1 (0.77) TK1CYP1A2CYP3A4TSHRBLM
SCHEMBL535680 1.00 TK1 (0.77) TK1CYP1A2CYP3A4TSHRBLM
SCHEMBL15457036 0.90 TK1 (0.75) TK1CYP1A2CYP3A4TSHRBLM
SCHEMBL12883747 0.90 TK1 (0.75) TK1CYP1A2CYP3A4TSHRBLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10385090-B2 Nucleotide derivative or salt thereof, nucleotide-derived 5′-phosphate ester or salt thereof, nucleotide-derived 3′-phosphoramidite compound or salt thereof, and polynucleotide NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY (JP) 2019-08-20 US disclosed
EP-2891714-B1 METHOD FOR ANALYZING TARGET NUCLEIC ACID, KIT, AND ANALYZER DNAFORM KK (JP) 2018-07-11 EP disclosed
US-9499576-B2 Compound, nucleic, acid, method for producing nucleic acid, and kit for producing nucleic acid RIKEN (JP) 2016-11-22 US disclosed
US-9499576-B2 Compound, nucleic, acid, method for producing nucleic acid, and kit for producing nucleic acid RIKEN (JP) 2016-11-22 US disclosed
US-20160311845-A1 NUCLEOTIDE DERIVATIVE OR SALT THEREOF, NUCLEOTIDE-DERIVED 5'-PHOSPHATE ESTER OR SALT THEREOF, NUCLEOTIDE-DERIVED 3'-PHOSPHORAMIDITE COMPOUND OR SALT THEREOF, AND POLYNUCLEOTIDE NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY (JP) 2016-10-27 US disclosed
US-20160311845-A1 NUCLEOTIDE DERIVATIVE OR SALT THEREOF, NUCLEOTIDE-DERIVED 5'-PHOSPHATE ESTER OR SALT THEREOF, NUCLEOTIDE-DERIVED 3'-PHOSPHORAMIDITE COMPOUND OR SALT THEREOF, AND POLYNUCLEOTIDE NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY (JP) 2016-10-27 US disclosed
US-9382286-B2 Treatment of EBV and KHSV infection and associated abnormal cellular proliferation EMORY UNIVERSITY (US) 2016-07-05 US disclosed
US-20150203902-A1 NUCLEIC ACID PROBE, METHOD FOR DESIGNING NUCLEIC ACID PROBE, AND METHOD FOR DETECTING TARGET SEQUENCE KABUSHIKI KAISHA DNAFORM (JP) 2015-07-23 US disclosed
EP-2891714-A1 METHOD FOR ANALYZING TARGET NUCLEIC ACID, KIT, AND ANALYZER Kabushiki Kaisha Dnaform (JP) 2015-07-08 EP disclosed
US-20150152496-A1 METHOD FOR ANALYZING TARGET NUCLEIC ACID, KIT, AND ANALYZER KABUSHIKI KAISHA DNAFORM (JP) 2015-06-04 US disclosed
EP-2660246-A1 COMPOUND, NUCLEIC ACID, METHOD FOR PRODUCING NUCLEIC ACID, AND KIT FOR PRODUCING NUCLEIC ACID Riken (JP) 2013-11-06 EP disclosed
US-20130289263-A1 COMPOUND, NUCLEIC ACID, METHOD FOR PRODUCING NUCLEIC ACID, AND KIT FOR PRODUCING NUCLEIC ACID RIKEN (JP) 2013-10-31 US disclosed
US-20130289263-A1 COMPOUND, NUCLEIC ACID, METHOD FOR PRODUCING NUCLEIC ACID, AND KIT FOR PRODUCING NUCLEIC ACID RIKEN (JP) 2013-10-31 US disclosed
US-8383792-B2 Compound having structure derived from mononucleoside or mononucleotide, nucleic acid, labeling substance, and method and kit for detection of nucleic acid RIKEN (JP) 2013-02-26 US disclosed
US-8383792-B2 Compound having structure derived from mononucleoside or mononucleotide, nucleic acid, labeling substance, and method and kit for detection of nucleic acid RIKEN (JP) 2013-02-26 US disclosed
US-8067162-B2 Replication; hybridization; kits RIKEN (JP) 2011-11-29 US disclosed
US-20100168052-A1 Treatment of EBV and KHSV Infection and Associated Abnormal Cellular Proliferation PHARMASSET, INC. (US) 2010-07-01 US disclosed
US-20100092971-A1 COMPOUND HAVING STRUCTURE DERIVED FROM MONONUCLEOSIDE OR MONONUCLEOTIDE, NUCLEIC ACID, LABELING SUBSTANCE, AND METHOD AND KIT FOR DETECTION OF NUCLEIC ACID RIKEN (JP) 2010-04-15 US disclosed
US-20080227104-A1 Replication; hybridization; kits RIKEN (JP) 2008-09-18 US disclosed
EP-1970453-A2 Primer, primer set, and nucleic acid amplification method and mutation detection method using the same Riken (JP) 2008-09-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100092971-A1 COMPOUND HAVING STRUCTURE DERIVED FROM MONONUCLEOSIDE OR MONONUCLEOTIDE, NUCLEIC ACID, LABELING SUBSTANCE, AND METHOD AND KIT FOR DETECTION OF NUCLEIC ACID NME1, NGLY1, DNTT TK1 21/4885CYP1A2 4856/4885CYP3A4 4806/4885
US-20080227104-A1 Replication; hybridization; kits PCNA, POLL, RNGTT TK1 300/4885CYP1A2 4851/4885CYP3A4 4220/4885
US-20100168052-A1 Treatment of EBV and KHSV Infection and Associated Abnormal Cellular Proliferation UMPS, ENTPD5, TK1 TK1 3/4885CYP1A2 2865/4885CYP3A4 1310/4885
US-20160311845-A1 NUCLEOTIDE DERIVATIVE OR SALT THEREOF, NUCLEOTIDE-DERIVED 5'-PHOSPHATE ESTER OR SALT THEREOF, NUCLEOTIDE-DERIVED 3'-PHOSPHORAMIDITE COMPOUND OR SALT THEREOF, AND POLYNUCLEOTIDE NT5C3B, PNP, NUDT1 TK1 32/4885CYP1A2 4511/4885CYP3A4 4502/4885
US-10385090-B2 Nucleotide derivative or salt thereof, nucleotide-derived 5′-phosphate ester or salt thereof, nucleotide-derived 3′-phosphoramidite compound or salt thereof, and polynucleotide SLC34A1, SLC34A2, SLC34A3 TK1 18/4885CYP1A2 4812/4885CYP3A4 4610/4885
US-20130289263-A1 COMPOUND, NUCLEIC ACID, METHOD FOR PRODUCING NUCLEIC ACID, AND KIT FOR PRODUCING NUCLEIC ACID DNTT, POLRMT, NSUN2 TK1 248/4885CYP1A2 4607/4885CYP3A4 4254/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.