Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 6/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.38 |
| ▸ | CBFB | Q13951 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5667519 | 0.92 | TSHR (0.42) | TSHRCASP1MPOALDH1A1LMNA | |
| SCHEMBL5361973 | 0.92 | TSHR (0.42) | TSHRCASP1MPOALDH1A1LMNA | |
| SCHEMBL7783672 | 0.77 | LMNA (0.43) | ALDH1A1LMNATP53HTTMAPT | |
| SCHEMBL23119669 | 0.69 | LMNA (0.67) | LMNATP53HTTMAPTKDM4E | |
| SCHEMBL7782299 | 0.66 | PDE7A (0.45) | ALDH1A1LMNAKDM4EGLAGAA | |
| SCHEMBL6977596 | 0.62 | KDM4E (0.73) | ALDH1A1LMNATP53HTTMAPT | |
| SCHEMBL16720690 | 0.60 | USP14 (0.53) | ALDH1A1LMNAHTTMAPTGAA | |
| SCHEMBL9436260 | 0.60 | ALDH1A1 (0.41) | TSHRCASP1ALDH1A1LMNAMAPT | |
| SCHEMBL30910102 | 0.60 | PDE7A (0.51) | TSHRCASP1ALDH1A1LMNAKDM4E | |
| SCHEMBL3150851 | 0.60 | PDE7A (0.51) | TSHRCASP1ALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679680-A | α-substituted hydrazides having calpain inhibitory activity | WARNER-LAMBERT COMPANY (US) | 1997-10-21 | — | — | US | claimed |
| US-5679680-A | α-substituted hydrazides having calpain inhibitory activity | WARNER-LAMBERT COMPANY (US) | 1997-10-21 | — | — | US | disclosed |