SCHEMBL890259

SCHEMBL890259

Cc1ccc2sc(C(C)C)nc2c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASR P41180 1/20 0.51
SMN1; SMN2 Q16637 3/20 0.49
MAPT P10636 2/20 0.49
TP53 P04637 1/20 0.49
DYRK1A Q13627 1/20 0.47
RAB9A P51151 3/20 0.41
AAK1 Q2M2I8 2/20 0.40
LOXL2 Q9Y4K0 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
CYP1A2 P05177 3/20 0.38
NQO2 P16083 1/20 0.38
NPC1 O15118 2/20 0.38
HSD17B10 Q99714 1/20 0.38
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
GLA P06280 1/20 0.37
GAA P10253 1/20 0.37
NFKB1 P19838 1/20 0.37
NFKB2 Q00653 1/20 0.37
RELA Q04206 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12810257 0.86 AAK1 (0.52) CASRSMN1; SMN2MAPTTP53DYRK1A
SCHEMBL12591857 0.85 RAB9A (0.58) CASRSMN1; SMN2MAPTTP53DYRK1A
SCHEMBL23328427 0.83 CASR (0.47) CASRSMN1; SMN2MAPTTP53DYRK1A
SCHEMBL12810070 0.82 AAK1 (0.46) CASRSMN1; SMN2MAPTTP53RAB9A
SCHEMBL889391 0.81 RAB9A (0.49) CASRSMN1; SMN2MAPTTP53RAB9A
SCHEMBL15481036 0.80 SMN1; SMN2 (0.56) SMN1; SMN2RAB9AAAK1LOXL2NPC1
SCHEMBL15481035 0.80 PPARA (0.51) CASRDYRK1ARAB9AAAK1LOXL2
SCHEMBL4284575 0.80 DYRK1A (0.50) CASRSMN1; SMN2MAPTDYRK1ARAB9A
SCHEMBL4973853 0.80 MAPT (0.53) CASRSMN1; SMN2MAPTTP53RAB9A
SCHEMBL24690847 0.80 AAK1 (0.40) CASRSMN1; SMN2TP53RAB9AAAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230373930-A1 AMINOIMIDAZOLE FPR2 AGONISTS BRISTOL MYERS SQUIBB CO (US) 2023-11-23 US disclosed
US-11701333-B2 Antibacterial compounds Kent Innovation & Enterprise (GB) 2023-07-18 US disclosed
US-11701333-B2 Antibacterial compounds Kent Innovation & Enterprise (GB) 2023-07-18 US disclosed
US-20230159512-A1 COMPOUNDS AS GLP-1R AGONISTS TERNS PHARMACEUTICALS, INC. 2023-05-25 US disclosed
WO-2023023310-A1 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 13 INHIBITORS AND METHODS OF USE THEREOF ENANTA PHARMACEUTICALS, INC. (US) 2023-02-23 WO disclosed
US-20210128501-A1 ANTIBACTERIAL COMPOUNDS KENT INNOVATION & ENTERPRISE, UNIVERSITY OF KENT (GB) 2021-05-06 US disclosed
US-20190112312-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE PHARMACYCLICS LLC (US) 2019-04-18 US disclosed
US-10189830-B2 Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders BIOELECTRON TECHNOLOGY CORPORATION (US) 2019-01-29 US disclosed
US-20170015671-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE PHARMACYCLICS LLC 2017-01-19 US disclosed
US-9533991-B2 Inhibitors of Bruton's tyrosine kinase PHARMACYCLICS LLC (US) 2017-01-03 US disclosed
US-20110142798-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. 2011-06-16 US disclosed
US-20110070197-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. 2011-03-24 US disclosed
US-20110070196-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. 2011-03-24 US disclosed
US-20110064695-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. 2011-03-17 US disclosed
US-20110064698-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. 2011-03-17 US disclosed
US-20110008288-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. 2011-01-13 US disclosed
WO-2010148006-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. (US) 2010-12-23 WO disclosed
US-20100316607-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. 2010-12-16 US disclosed
US-20100266543-A1 LINKED DIBENZIMIDAZOLE ANTIVIRALS ENANTA PHARMACEUTICALS, INC. 2010-10-21 US disclosed
US-20100260715-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. 2010-10-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (16 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11701333-B2 Antibacterial compounds ARF1, ARL1, TLR1 CASR 4392/4885SMN1; SMN2 3087/4885MAPT 2612/4885
US-20100260715-A1 HEPATITIS C VIRUS INHIBITORS HAVCR2, SLC10A1, EIF2AK2 CASR 4563/4885SMN1; SMN2 4162/4885MAPT 4133/4885
US-20100316607-A1 HEPATITIS C VIRUS INHIBITORS HAVCR2, SLC10A1, EIF2AK2 CASR 4563/4885SMN1; SMN2 4162/4885MAPT 4133/4885
US-20230159512-A1 COMPOUNDS AS GLP-1R AGONISTS GLP1R, GIPR, GCGR CASR 218/4885SMN1; SMN2 2580/4885MAPT 3437/4885
US-20170015671-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE BTK, LYN, SYK CASR 4746/4885SMN1; SMN2 4440/4885MAPT 4267/4885
US-20110142798-A1 HEPATITIS C VIRUS INHIBITORS HAVCR2, SLC10A1, EIF2AK2 CASR 4563/4885SMN1; SMN2 4162/4885MAPT 4133/4885
US-20110008288-A1 HEPATITIS C VIRUS INHIBITORS HAVCR2, SLC10A1, EIF2AK2 CASR 4563/4885SMN1; SMN2 4162/4885MAPT 4133/4885
US-20100266543-A1 LINKED DIBENZIMIDAZOLE ANTIVIRALS EIF2AK2, ZC3HAV1, NSUN2 CASR 4854/4885SMN1; SMN2 3504/4885MAPT 3942/4885
US-20110070196-A1 HEPATITIS C VIRUS INHIBITORS HAVCR2, EIF2AK2, SLC10A1 CASR 4527/4885SMN1; SMN2 4269/4885MAPT 4286/4885
US-20190112312-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE BTK, LYN, SYK CASR 4746/4885SMN1; SMN2 4440/4885MAPT 4267/4885
US-20110064698-A1 HEPATITIS C VIRUS INHIBITORS HAVCR2, EIF2AK2, SLC10A1 CASR 4527/4885SMN1; SMN2 4269/4885MAPT 4286/4885
US-20110064695-A1 HEPATITIS C VIRUS INHIBITORS HAVCR2, EIF2AK2, SLC10A1 CASR 4527/4885SMN1; SMN2 4269/4885MAPT 4286/4885
US-20230373930-A1 AMINOIMIDAZOLE FPR2 AGONISTS FPR2, FPR1, FPR3 CASR 1563/4885SMN1; SMN2 4462/4885MAPT 4406/4885
US-10189830-B2 Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders NQO1, COQ8A, NDUFAB1 CASR 4810/4885SMN1; SMN2 303/4885MAPT 664/4885
US-20110070197-A1 HEPATITIS C VIRUS INHIBITORS HAVCR2, EIF2AK2, SLC10A1 CASR 4527/4885SMN1; SMN2 4269/4885MAPT 4286/4885
US-20210128501-A1 ANTIBACTERIAL COMPOUNDS ARF1, ARL1, TLR1 CASR 4392/4885SMN1; SMN2 3087/4885MAPT 2612/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.