Water

Water

SCHEMBL8908357

C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(OC(=O)O)cn1c23.O

nearest known ligand 0.78

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A known ✓ P04350 7/20 0.78
TUBB known ✓ P07437 7/20 0.78
TUBA3C known ✓ P0DPH7 7/20 0.78
TUBA1B known ✓ P68363 7/20 0.78
TUBA4A known ✓ P68366 7/20 0.78
TUBB4B known ✓ P68371 7/20 0.78
TUBB3 known ✓ Q13509 7/20 0.78
TUBB2A known ✓ Q13885 7/20 0.78
TUBB8 known ✓ Q3ZCM7 7/20 0.78
TUBA3E known ✓ Q6PEY2 7/20 0.78
TUBA1A known ✓ Q71U36 7/20 0.78
TUBA1C known ✓ Q9BQE3 7/20 0.78
TUBB6 known ✓ Q9BUF5 7/20 0.78
TUBB2B known ✓ Q9BVA1 7/20 0.78
TUBB1 known ✓ Q9H4B7 7/20 0.78
HDAC1 known ✓ Q13547 7/20 0.54
HDAC2 known ✓ Q92769 7/20 0.54
HDAC6 known ✓ Q9UBN7 7/20 0.54
HDAC3 known ✓ O15379 6/20 0.52
HDAC4 known ✓ P56524 6/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2853298 0.99 KDM4E (0.78) KDM4ETUBB4ATUBBTUBA3CTUBA1B
SCHEMBL5195420 0.99 KDM4E (0.78) KDM4ETUBB4ATUBBTUBA3CTUBA1B
SCHEMBL9119184 0.89 KDM4E (0.64) KDM4ETUBB4ATUBBTUBA3CTUBA1B
Levofloxacin Anhydrous SCHEMBL891190 0.88 KDM4E (1.00) KDM4ETUBB4ATUBBTUBA3CTUBA1B
Levofloxacin Anhydrous SCHEMBL30009030 0.88 KDM4E (1.00) KDM4ETUBB4ATUBBTUBA3CTUBA1B
Levofloxacin Anhydrous SCHEMBL1650602 0.88 KDM4E (1.00) KDM4ETUBB4ATUBBTUBA3CTUBA1B
Ofloxacin SCHEMBL6092282 0.88 KDM4E (1.00) KDM4ETUBB4ATUBBTUBA3CTUBA1B
Ofloxacin SCHEMBL6090650 0.88 KDM4E (1.00) KDM4ETUBB4ATUBBTUBA3CTUBA1B
Levofloxacin Anhydrous SCHEMBL27810870 0.87 KDM4E (0.98) KDM4ETUBB4ATUBBTUBA3CTUBA1B
Ofloxacin SCHEMBL24373 0.87 KDM4E (1.00) KDM4ETUBB4ATUBBTUBA3CTUBA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0444678-B1 Process for selectively producing hydrate crystals DAIICHI SEIYAKU CO (JP) 1997-09-03 EP claimed