Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 1/20 | 0.42 |
| ▸ | F2R | P25116 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CCKBR | P32239 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8910706 | 0.88 | F2R (0.38) | P2RX1F2RRENAKR1C3MDM2 | |
| SCHEMBL8909363 | 0.84 | P2RX1 (0.52) | P2RX1F2RRENAKR1C3MDM2 | |
| SCHEMBL8910700 | 0.76 | REN (0.40) | P2RX1F2RRENAKR1C3MDM2 | |
| SCHEMBL8908848 | 0.72 | F2R (0.37) | P2RX1F2RRENAKR1C3MDM2 | |
| SCHEMBL8909154 | 0.68 | REN (0.41) | P2RX1F2RREN | |
| SCHEMBL8910563 | 0.67 | REN (0.41) | P2RX1RENKDM4EHSD17B10TSHR | |
| SCHEMBL8909458 | 0.67 | PYGL (0.36) | P2RX1RENAKR1C3KDM4EAR | |
| SCHEMBL8909221 | 0.66 | P2RX1 (0.45) | P2RX1REN | |
| SCHEMBL8910552 | 0.66 | REN (0.36) | P2RX1F2RREN | |
| SCHEMBL8910252 | 0.66 | KDM4E (0.39) | RENAKR1C3KDM4EHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |