SCHEMBL8914696

SCHEMBL8914696

CNC(=O)C(Cc1ccc(F)cc1)NC(=O)C(NC)C(C)c1ccc2ccccc2c1

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FCER2 P06734 1/20 0.50
MMP9 P14780 2/20 0.49
MMP8 P22894 2/20 0.49
MMP2 P08253 1/20 0.49
MC4R P32245 7/20 0.47
MC3R P41968 7/20 0.47
MC1R Q01726 7/20 0.47
MME P08473 2/20 0.42
ACE P12821 1/20 0.42
CPA1 P15085 1/20 0.42
ACE2 Q9BYF1 1/20 0.42
MMP1 P03956 6/20 0.42
CNR1 P21554 1/20 0.41
CNR2 P34972 1/20 0.41
PLAT P00750 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8905430 0.92 FCER2 (0.56) FCER2MMP9MMP8MMP2MME
SCHEMBL8914878 0.81 HTRA1 (0.46) FCER2MMP9MMP8MMP2
SCHEMBL8235027 0.80 MMP9 (0.43) FCER2MMP9MMP8MMEACE
SCHEMBL7132131 0.78 MMP2 (0.54) FCER2MMP9MMP8MMP2MME
SCHEMBL8906164 0.74 CYP1A2 (0.49)
SCHEMBL8206981 0.72 FCER2 (0.60) FCER2MMP9MMP8MMP2MME
SCHEMBL7771306 0.72 CA2 (0.45)
SCHEMBL6318078 0.72 MMP1 (0.51) FCER2MMEACEMMP1CNR1
SCHEMBL27488809 0.72 MMP1 (0.51) FCER2MMEACEMMP1CNR1
SCHEMBL6318813 0.70 MMP9 (0.47) FCER2MMP9MMP8MMP2MC4R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997023508-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1997-07-03 WO disclosed