Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | SGK1 | O00141 | 3/20 | 0.36 |
| ▸ | ALPL | P05186 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916165 | 0.90 | LMNA (0.40) | PLAUPLATSGK1AKR1C3AKR1C2 | |
| SCHEMBL8916678 | 0.88 | SGK1 (0.38) | SGK1BRD4SLC40A1ALOX5APFEN1 | |
| SCHEMBL8917778 | 0.87 | SGK1 (0.39) | SGK1BRD4SCN9ASPRALOX5AP | |
| SCHEMBL8917188 | 0.84 | PLAU (0.48) | PLAUPLATSCN9A | |
| SCHEMBL8917798 | 0.79 | MCL1 (0.47) | SGK1 | |
| SCHEMBL8917485 | 0.78 | ALDH1A1 (0.49) | — | |
| SCHEMBL8917459 | 0.78 | MCL1 (0.41) | ALOX5APFEN1 | |
| SCHEMBL8917334 | 0.77 | MEN1 (0.42) | PLAUSLC40A1 | |
| SCHEMBL8694062 | 0.76 | SLC2A1 (0.32) | PLAUPLAT | |
| SCHEMBL8918579 | 0.76 | ALDH1A1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696143-A | ARTHRITIS THERAPY | G.D. SEARLE & CO. | 1997-12-09 | — | — | US | disclosed |