Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917459 | 0.91 | MCL1 (0.41) | MCL1ALDH1A1L3MBTL1LMNAGLA | |
| SCHEMBL8917485 | 0.91 | ALDH1A1 (0.49) | MCL1ALDH1A1L3MBTL1LMNAGLA | |
| SCHEMBL8918579 | 0.88 | ALDH1A1 (0.40) | MCL1ALDH1A1L3MBTL1LMNAGLA | |
| SCHEMBL8916165 | 0.88 | LMNA (0.40) | MCL1ALDH1A1L3MBTL1LMNAGLA | |
| SCHEMBL8920658 | 0.86 | ALDH1A1 (0.39) | MCL1ALDH1A1L3MBTL1LMNAGLA | |
| SCHEMBL8917277 | 0.84 | TRPV4 (0.34) | MCL1ALDH1A1TSHRRAB9AFBP1 | |
| SCHEMBL8917778 | 0.82 | SGK1 (0.39) | MCL1DDR1SGK1 | |
| SCHEMBL8916678 | 0.82 | SGK1 (0.38) | MCL1ALDH1A1L3MBTL1LMNAGLA | |
| SCHEMBL8917282 | 0.79 | PLAU (0.38) | SGK1 | |
| SCHEMBL8918537 | 0.75 | FBP1 (0.33) | ALDH1A1L3MBTL1LMNAGLAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696143-A | ARTHRITIS THERAPY | G.D. SEARLE & CO. | 1997-12-09 | — | — | US | disclosed |