Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 4/20 | 0.47 |
| ▸ | CD74 | P04233 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918738 | 0.88 | ALDH1A1 (0.50) | MIFMAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL8625029 | 0.86 | NPC1 (0.48) | MIFCD74NPC1TP53MAPT | |
| SCHEMBL7316292 | 0.81 | NPC1 (0.63) | MIFCD74NPC1POLBKDM4E | |
| SCHEMBL8921274 | 0.78 | ALDH1A1 (0.45) | MAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL8918560 | 0.78 | LMNA (0.38) | KDM4EALDH1A1PDE1BTSHRLMNA | |
| SCHEMBL8624599 | 0.78 | ADORA2B (0.35) | KDM4EALDH1A1PDE1B | |
| SCHEMBL8917032 | 0.76 | CYP1A2 (0.36) | TP53MAPTALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8626905 | 0.74 | ALDH1A1 (0.43) | TP53MAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL8919271 | 0.71 | ALDH1A1 (0.53) | TP53MAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL8626022 | 0.70 | ALDH1A1 (0.63) | NPC1TP53MAPTPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | disclosed |
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | disclosed |