Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918738 | 0.90 | ALDH1A1 (0.50) | LMNATSHRALDH1A1MAPK1IDO1 | |
| SCHEMBL8919804 | 0.82 | LMNA (0.42) | LMNATSHRALDH1A1MAPK1IDO1 | |
| SCHEMBL8918012 | 0.78 | MIF (0.47) | LMNATSHRALDH1A1PDE1BHTT | |
| SCHEMBL8917032 | 0.78 | CYP1A2 (0.36) | ALDH1A1MAPK1MEN1KMT2ASIGMAR1 | |
| SCHEMBL8624599 | 0.75 | ADORA2B (0.35) | ALDH1A1SIGMAR1PDE1BSLC6A2HTR2A | |
| SCHEMBL8626905 | 0.75 | ALDH1A1 (0.43) | LMNAALDH1A1SIGMAR1PDE1BPKM | |
| SCHEMBL8625029 | 0.64 | NPC1 (0.48) | TSHRALDH1A1HTTKDM4E | |
| SCHEMBL8917897 | 0.64 | SIGMAR1 (0.42) | LMNAALDH1A1MAPK1SIGMAR1SMN1; SMN2 | |
| SCHEMBL8918636 | 0.64 | HSD17B10 (0.43) | LMNATSHRALDH1A1MAPK1PKM | |
| SCHEMBL8626022 | 0.63 | ALDH1A1 (0.63) | LMNATSHRALDH1A1MAPK1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | disclosed |
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | disclosed |