Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918738 | 0.85 | ALDH1A1 (0.50) | KDM4EALDH1A1SMN1; SMN2MAPTSIGMAR1 | |
| SCHEMBL8918636 | 0.83 | HSD17B10 (0.43) | KMOKDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL8918012 | 0.78 | MIF (0.47) | KDM4EALDH1A1HSD17B10SMN1; SMN2MAPT | |
| SCHEMBL8917032 | 0.76 | CYP1A2 (0.36) | KMOALDH1A1HSD17B10SMN1; SMN2MAPT | |
| SCHEMBL8624599 | 0.73 | ADORA2B (0.35) | KMOKDM4EALDH1A1SIGMAR1 | |
| SCHEMBL8626905 | 0.73 | ALDH1A1 (0.43) | KDM4EALDH1A1HSD17B10SMN1; SMN2MAPT | |
| SCHEMBL8626022 | 0.66 | ALDH1A1 (0.63) | KDM4EALDH1A1HSD17B10SMN1; SMN2MAPT | |
| SCHEMBL8625029 | 0.65 | NPC1 (0.48) | KDM4EALDH1A1HSD17B10MAPTNPC1 | |
| SCHEMBL11343195 | 0.64 | MIF (0.60) | ALDH1A1SMN1; SMN2LMNATSHRRAB9A | |
| SCHEMBL8919804 | 0.64 | LMNA (0.42) | KDM4EALDH1A1HSD17B10SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | disclosed |
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | disclosed |