SCHEMBL8925408

SCHEMBL8925408

O=C(NCC1CCNCC1)NC12CC3CC(CC(C3)C1)C2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 18/20 1.00
EPHX1 P07099 17/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5144022 0.98 EPHX2 (0.97) EPHX2EPHX1
SCHEMBL8066381 0.91 EPHX1 (0.84) EPHX2EPHX1
SCHEMBL12196135 0.84 EPHX1 (1.00) EPHX2EPHX1
SCHEMBL15172335 0.83 EPHX1 (0.71) EPHX2EPHX1
SCHEMBL3960013 0.82 EPHX1 (0.73) EPHX2EPHX1
SCHEMBL4535957 0.78 EPHX1 (1.00) EPHX2EPHX1
SCHEMBL652237 0.77 EPHX1 (1.00) EPHX2EPHX1
SCHEMBL8925131 0.77 EPHX1 (1.00) EPHX2EPHX1
SCHEMBL8234307 0.76 EPHX2 (1.00) EPHX2EPHX1
SCHEMBL8233455 0.75 EPHX1 (1.00) EPHX2EPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230301949-A1 TREATMENT OF NEURODEVELOPMENTAL DISORDERS CHIBA UNIVERSITY (JP) 2023-09-28 US disclosed
US-11723929-B2 Methods of improving cell-based therapy THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-08-15 US disclosed
US-11690837-B2 Methods of improving cell-based therapy THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-07-04 US disclosed
US-20180200244-A1 METHODS OF IMPROVING CELL-BASED THERAPY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-07-19 US disclosed
CN-102464631-B Piperazine substituted 1,3-2-substituted carbamide compounds and the substituted amides compound of piperazine and its production and use 中国科学院上海药物研究所 2016-08-10 CN disclosed
US-20160008342-A1 METHODS OF IMPROVING CELL-BASED THERAPY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-01-14 US disclosed
US-9029550-B2 Conformationally restricted urea inhibitors of soluble epoxide hydrolase THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-05-12 US disclosed
US-20130274476-A1 CONFORMATIONALLY RESTRICTED UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE UNIV CALIFORNIA (US) 2013-10-17 US disclosed
US-8501783-B2 Conformationally restricted urea inhibitors of soluble epoxide hydrolase THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-08-06 US disclosed
US-20130137726-A1 CONFORMATIONALLY RESTRICTED UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-05-30 US disclosed
US-20130137726-A1 CONFORMATIONALLY RESTRICTED UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-05-30 US disclosed
US-8399425-B2 Alleviating neuropathic pain with EETs and sEH inhibitors THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-03-19 US disclosed
US-20130065936-A1 MODULATION OF BIOACTIVE EPOXY-FATTY ACID LEVELS BY PHOSPHODIESTERASE INHIBITORS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-03-14 US disclosed
US-20130045172-A1 USE OF CIS-EPOXYEICOSATRIENOIC ACIDS AND INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO TREAT CONDITIONS MEDIATED BY PBR, CB2, and NK2 RECEPTORS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-02-21 US disclosed
US-8188289-B2 Conformationally restricted urea inhibitors of soluble epoxide hydrolase THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-05-29 US disclosed
US-20120046251-A1 INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO INHIBIT OR PREVENT NIACIN-INDUCED FLUSHING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-23 US disclosed
US-20110230504-A1 ALLEVIATING DISORDERS WITH COMBINING AGENTS THAT INCREASE EPOXYGENATED FATTY ACIDS AND AGENTS THAT INCREASE cAMP The Regents Of The University Of California Office Of Technology (US) 2011-09-22 US disclosed
US-20080279912-A1 Use of Cis-Epoxyeicosatrienoic Acids And Inhibitors of Soluble Epoxide Hydrolase to Alleviate Eye Disorders REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF TECHNOLOGY TRANSFER (US) 2008-11-13 US disclosed
US-20070225283-A1 CONFORMATIONALLY RESTRICTED UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-09-27 US disclosed
US-20070225283-A1 CONFORMATIONALLY RESTRICTED UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-09-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230301949-A1 TREATMENT OF NEURODEVELOPMENTAL DISORDERS FABP7, ADH1B, ELOVL1 EPHX2 51/4885EPHX1 25/4885
US-20160008342-A1 METHODS OF IMPROVING CELL-BASED THERAPY ELOVL1, ELOVL3, IL2 EPHX2 127/4885EPHX1 116/4885
US-11723929-B2 Methods of improving cell-based therapy EPHX1, EPHX2, NCEH1 EPHX2 2/4885EPHX1 1/4885
US-20110230504-A1 ALLEVIATING DISORDERS WITH COMBINING AGENTS THAT INCREASE EPOXYGENATED FATTY ACIDS AND AGENTS THAT INCREASE cAMP FAAH, EPHX1, FAAH2 EPHX2 4/4885EPHX1 2/4885
US-20080279912-A1 Use of Cis-Epoxyeicosatrienoic Acids And Inhibitors of Soluble Epoxide Hydrolase to Alleviate Eye Disorders EPHX1, PTGES, PTGS1 EPHX2 5/4885EPHX1 1/4885
US-20180200244-A1 METHODS OF IMPROVING CELL-BASED THERAPY ELOVL1, ELOVL3, IL2 EPHX2 127/4885EPHX1 116/4885
US-11690837-B2 Methods of improving cell-based therapy ELOVL1, ELOVL3, IL2 EPHX2 127/4885EPHX1 116/4885
US-20120046251-A1 INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO INHIBIT OR PREVENT NIACIN-INDUCED FLUSHING EPHX1, NCEH1, FAAH EPHX2 6/4885EPHX1 1/4885
US-20070225283-A1 CONFORMATIONALLY RESTRICTED UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE EPHX1, EPHX2, NCEH1 EPHX2 2/4885EPHX1 1/4885
US-20130065936-A1 MODULATION OF BIOACTIVE EPOXY-FATTY ACID LEVELS BY PHOSPHODIESTERASE INHIBITORS PTGIS, PDE2A, PDE3B EPHX2 45/4885EPHX1 29/4885
US-20130274476-A1 CONFORMATIONALLY RESTRICTED UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE EPHX1, EPHX2, NCEH1 EPHX2 2/4885EPHX1 1/4885
US-20130045172-A1 USE OF CIS-EPOXYEICOSATRIENOIC ACIDS AND INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE TO TREAT CONDITIONS MEDIATED BY PBR, CB2, and NK2 RECEPTORS CNR2, EPHX2, CNR1 EPHX2 2/4885EPHX1 8/4885
US-20130137726-A1 CONFORMATIONALLY RESTRICTED UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE EPHX1, EPHX2, NCEH1 EPHX2 2/4885EPHX1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.