Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Pyrophosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | PEPD | P12955 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triphosphate SCHEMBL28141385 | 0.88 | FDPS (0.47) | FDPSBLMTDP1SLC34A1CA1 | |
| Pyrophosphoric Acid SCHEMBL8931250 | 0.85 | FDPS (0.59) | FDPSBLMTDP1SLC34A1CA1 | |
| Pyrophosphoric Acid SCHEMBL27481503 | 0.83 | FDPS (0.77) | FDPSBLMTDP1SLC34A1CA2 | |
| Pyrophosphoric Acid SCHEMBL31219450 | 0.83 | FDPS (0.91) | FDPSBLMTDP1SLC34A1CA2 | |
| Pyrophosphoric Acid SCHEMBL5575855 | 0.80 | FDPS (0.71) | FDPSBLMTDP1SLC34A1CA1 | |
| Pyrophosphoric Acid SCHEMBL26101622 | 0.80 | FDPS (0.71) | FDPSBLMTDP1SLC34A1CA1 | |
| Pyrophosphoric Acid SCHEMBL28159392 | 0.80 | FDPS (0.71) | FDPSBLMTDP1SLC34A1CA1 | |
| Pyrophosphoric Acid SCHEMBL21110677 | 0.79 | FDPS (0.83) | FDPSBLMTDP1SLC34A1CA2 | |
| Phosphoric Acid SCHEMBL27634263 | 0.79 | SLC34A1 (0.50) | TDP1SLC34A1CA1CA2MEN1 | |
| Phosphoric Acid SCHEMBL11299297 | 0.79 | SLC34A1 (0.50) | TDP1SLC34A1CA1CA2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0782438-A1 | ORAL COMPOSITIONS | UNILEVER N.V. (NL) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009034-A1 | ORAL COMPOSITIONS | UNILEVER N.V. (NL) | 1996-03-28 | — | — | WO | disclosed |