SCHEMBL8945494

SCHEMBL8945494

C[Si](C)(C)Nc1c(Cl)cccc1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 4/20 0.39
ADRA2C P18825 4/20 0.39
ADRA1D P25100 3/20 0.39
ADRA1A P35348 3/20 0.39
ADRA1B P35368 3/20 0.39
ADRA2B P18089 3/20 0.38
GAA P10253 3/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2A6 P11509 1/20 0.38
LMNA P02545 3/20 0.37
TYK2 P29597 1/20 0.37
MEN1 O00255 1/20 0.37
SLC22A1 O15245 1/20 0.37
SLC22A3 O75751 1/20 0.37
HTR1A P08908 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
HRH2 P25021 1/20 0.37
CYP2C19 P33261 1/20 0.37
OPRK1 P41145 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8903199 0.75 NLRP3 (0.40) ADRA2AADRA2CADRA1DADRA1AADRA1B
SCHEMBL6857887 0.73 TSHR (0.45) ADRA2AADRA2CADRA2BCYP1A2LMNA
SCHEMBL9375905 0.73 LMNA (0.47) GAACYP1A2LMNAMEN1CYP2C9
SCHEMBL6676436 0.72 CYP1A2 (0.39) CYP1A2CYP2A6LMNAMEN1CYP2D6
SCHEMBL463746 0.70 CYP1A2 (0.43) ADRA2AADRA2CADRA1DADRA1AADRA1B
SCHEMBL9771602 0.70 KMT2A (0.35) GAALMNAMEN1KMT2A
SCHEMBL1686581 0.69 ADRA2A (0.52) ADRA2AADRA2CADRA1DADRA1AADRA1B
SCHEMBL11802445 0.67 TSHR (0.50) GAALMNATYK2TSHRPOLB
SCHEMBL6575645 0.67 GABRA1 (0.44) CYP1A2LMNAMEN1KMT2AHIF1A
SCHEMBL11409613 0.65 CYP1A2 (0.43) ADRA2AADRA2CADRA1DADRA1AADRA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5003096-A Alkylsilylaniline intermediates for herbicides THE DOW CHEMICAL COMPANY (US) 1991-03-26 US claimed
US-4910306-A Combining a sulfonyl halide with N-trialkylsilylaniline THE DOW CHEMICAL COMPANY (US) 1990-03-20 US claimed
CN-108349986-B Novel crystal form of diclosulam, preparation method and application thereof 江苏龙灯化学有限公司 2022-03-01 CN disclosed
US-9643973-B1 Crystalline form of diclosulam, a process for its preparation and use of the same ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED (HK) 2017-05-09 US disclosed
US-5494887-A Ring annulated 5-alkoxy-n-aryl[1,2,4]triazolo[1,5-C]-pyrimidine-2-sulfonamide herbicides DOWELANCO (US) 1996-02-27 US disclosed
EP-0434624-B1 Triazolylsulfonamides CIBA GEIGY AG (CH) 1995-02-08 EP disclosed
EP-0340828-B1 5-Fluoromethyl-1,2,4-triazolo(1,5-a)-pyrimidine-2-sulfonamides, process for their preparation and compositions for their use as herbicides DOWELANCO (US) 1994-03-02 EP disclosed
EP-0343752-B1 Alkoxy-1,2,4-triazolo (1,5-c) pyrimidine-2-sulfonamides, process for their preparation and intermediates DOWELANCO (US) 1993-12-01 EP disclosed
US-5217521-A Preemergence, postemergence herbicides CIBA-GEIGY CORPORATION (US) 1993-06-08 US disclosed
US-5163995-A For use with grassy crops and soybeans DOWELANCO (US) 1992-11-17 US disclosed
EP-0434624-A1 Triazolylsulfonamides CIBA-GEIGY AG (CH) 1991-06-26 EP disclosed
US-4979981-A BIODEGRADABLE HERBICIDES THE DOW CHEMICAL COMPANY (US) 1990-12-25 US disclosed
US-4910306-A Combining a sulfonyl halide with N-trialkylsilylaniline THE DOW CHEMICAL COMPANY (US) 1990-03-20 US disclosed
US-4904301-A HERBICIDE THE DOW CHEMICAL COMPANY (US) 1990-02-27 US disclosed
WO-1989011782-A1 ALKOXY-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE-2-SULFONAMIDES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THE DOW CHEMICAL COMPANY (US) 1989-12-14 WO disclosed
EP-0343752-A1 Alkoxy-1,2,4-triazolo (1,5-c) pyrimidine-2-sulfonamides, process for their preparation and intermediates DowElanco (US) 1989-11-29 EP disclosed
EP-0340828-A1 5-Fluoromethyl-1,2,4-triazolo(1,5-a)-pyrimidine-2-sulfonamides, process for their preparation and compositions for their use as herbicides DowElanco (US) 1989-11-08 EP disclosed
WO-1989010368-A1 5-FLUOROMETHYL-1,2,4-TRIAZOLO[1,5-a]-PYRIMIDINE-2-SULFONAMIDES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS FOR THEIR USE AS HERBICIDES THE DOW CHEMICAL COMPANY (US) 1989-11-02 WO disclosed
US-4799952-A Herbicidal imidazolo(1,2-a)pyrimidine-2-sulfonanilides THE DOW CHEMICAL COMPANY (US) 1989-01-24 US disclosed
US-4731446-A PRE- AND POSTEMERGENCE HERBICIDES THE DOW CHEMICAL COMPANY (US) 1988-03-15 US disclosed