Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 known ✓ | P36888 | 1/20 | 0.38 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.37 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | ICMT | O60725 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8959605 | 1.00 | HTR6 (0.48) | HTR6ICMTGSK3BPLA2G4AKDR | |
| SCHEMBL8959690 | 0.89 | HTR6 (0.51) | HTR6ICMTGSK3BKDRFLT3 | |
| Fumaric Acid SCHEMBL8959560 | 0.78 | TRPM5 (0.36) | ICMTCA2CA5ACA9LMNA | |
| Fumaric Acid SCHEMBL8959571 | 0.78 | TRPM5 (0.36) | ICMTCA2CA5ACA9LMNA | |
| SCHEMBL8959614 | 0.75 | ICMT (0.39) | ICMTPLA2G4APOLBCNR1CNR2 | |
| Fumaric Acid SCHEMBL8959756 | 0.73 | TRPM5 (0.47) | GSK3BKDRFLT3ALDH1A1 | |
| Fumaric Acid SCHEMBL8959767 | 0.73 | TRPM5 (0.47) | GSK3BKDRFLT3ALDH1A1 | |
| Fumaric Acid SCHEMBL8959697 | 0.73 | HTR2A (0.48) | HTR6LMNAKDM4EALDH1A1 | |
| Fumaric Acid SCHEMBL8959686 | 0.73 | HTR2A (0.48) | HTR6LMNAKDM4EALDH1A1 | |
| SCHEMBL8959603 | 0.69 | RAB9A (0.43) | ICMTPLA2G4APOLBMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |